MedKoo Cat#: 574433 | Name: Tandospirone HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tandospirone, also known as SM-3997, is a 5-HT1A receptor partial agonist that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors. It is inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. It displays anxiolytic activity.

Chemical Structure

Tandospirone HCl
Tandospirone HCl
CAS#99095-10-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 574433

Name: Tandospirone HCl

CAS#: 99095-10-0 (HCl)

Chemical Formula: C21H30ClN5O2

Exact Mass: 419.2088

Molecular Weight: 419.95

Elemental Analysis: C, 60.06; H, 7.20; Cl, 8.44; N, 16.68; O, 7.62

Price and Availability

Size Price Availability Quantity
10mg USD 500.00 2 Weeks
50mg USD 1,125.00 2 Weeks
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Synonym
SM-3997; SM 3997; SM3997; Tandospirone hydrochloride, Tandospirone HCl
IUPAC/Chemical Name
(3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride
InChi Key
ACVFJYKNBOHIMH-DPFKZJTMSA-N
InChi Code
InChI=1S/C21H29N5O2.ClH/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21;/h3,6-7,15-18H,1-2,4-5,8-14H2;1H/t15-,16+,17+,18-;
SMILES Code
[H][C@]13[C@](C(N(CCCCN4CCN(C5=NC=CC=N5)CC4)C3=O)=O)([H])[C@@H]2CC[C@H]1C2.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 419.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Hamik et al (1990) Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry 28 99 PMID: 1974152 Pollard et al (1992) Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol. 221 297 PMID: 1358655 Matsubara et al (2006) Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-DArgic systems in rats with unilateral 6-hydroxyDA-generated lesions. Brain Res. 1112 126 PMID: 16884702