CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase. It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 µM.
MedKoo Cat#: 558987
Name: CU-32
CAS#: 2400954-16-5
Chemical Formula: C11H10IN5O2
Exact Mass: 370.9879
Molecular Weight: 371.14
Elemental Analysis: C, 35.60; H, 2.72; I, 34.19; N, 18.87; O, 8.62
The following data is based on the product molecular weight 371.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
