MedKoo Cat#: 525424 | Name: Aza-THIP

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aza-THIP is a novel selective GABA-C antagonist.

Chemical Structure

Aza-THIP
Aza-THIP
CAS#654666-65-6

Theoretical Analysis

MedKoo Cat#: 525424

Name: Aza-THIP

CAS#: 654666-65-6

Chemical Formula: C6H9N3O

Exact Mass: 139.0746

Molecular Weight: 139.16

Elemental Analysis: C, 51.79; H, 6.52; N, 30.20; O, 11.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Aza-THIP
IUPAC/Chemical Name
4,5,6,7-Tetrahydropyrazolo[5,4-c]pyridin-3-ol
InChi Key
UPMMUUFLHUEUKP-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H9N3O/c10-6-4-1-2-7-3-5(4)8-9-6/h7H,1-3H2,(H2,8,9,10)
SMILES Code
OC1=NNC2=C1CCNC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 139.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Valembois S, Krall J, Frølund B, Steffansen B. Imidazole-4-acetic acid, a new lead structure for interaction with the taurine transporter in outer blood-retinal barrier cells. Eur J Pharm Sci. 2017 May 30;103:77-84. doi: 10.1016/j.ejps.2017.02.041. Epub 2017 Mar 1. PubMed PMID: 28259832. 2: Johnston GA, Chebib M, Hanrahan JR, Mewett KN. Neurochemicals for the investigation of GABA(C) receptors. Neurochem Res. 2010 Dec;35(12):1970-7. doi: 10.1007/s11064-010-0271-7. Epub 2010 Oct 21. Review. PubMed PMID: 20963487. 3: Krehan D, Frølund B, Ebert B, Nielsen B, Krogsgaard-Larsen P, Johnston GA, Chebib M. Aza-THIP and related analogues of THIP as GABA C antagonists. Bioorg Med Chem. 2003 Nov 17;11(23):4891-6. PubMed PMID: 14604650. 4: Johnston GA, Chebib M, Hanrahan JR, Mewett KN. GABA(C) receptors as drug targets. Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):260-8. Review. PubMed PMID: 12871036.