MedKoo Cat#: 534919 | Name: Glybuthiazol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Glybuthiazol is a bioactive chemical.

Chemical Structure

Glybuthiazol
Glybuthiazol
CAS#535-65-9

Theoretical Analysis

MedKoo Cat#: 534919

Name: Glybuthiazol

CAS#: 535-65-9

Chemical Formula: C12H16N4O2S2

Exact Mass: 312.0715

Molecular Weight: 312.41

Elemental Analysis: C, 46.14; H, 5.16; N, 17.93; O, 10.24; S, 20.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Glybuthiazol
IUPAC/Chemical Name
Sulfanilamide, N(sup 1)-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-
InChi Key
DVQVBLBKEXITIK-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H16N4O2S2/c1-12(2,3)10-14-15-11(19-10)16-20(17,18)9-6-4-8(13)5-7-9/h4-7H,13H2,1-3H3,(H,15,16)
SMILES Code
O=S(NC1=NN=C(C(C)(C)C)S1)(C2=CC=C(N)C=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 312.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Harris HM, Eans SO, Ganno ML, Davis JC, Dooley CT, McLaughlin JP, Nefzi A. Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs. Org Biomol Chem. 2019 Jun 7;17(21):5305-5315. doi: 10.1039/c9ob00882a. Epub 2019 May 16. PMID: 31094391; PMCID: PMC6637423. 2: Smith CC, Zhang C, Lin KC, Lasater EA, Zhang Y, Massi E, Damon LE, Pendleton M, Bashir A, Sebra R, Perl A, Kasarskis A, Shellooe R, Tsang G, Carias H, Powell B, Burton EA, Matusow B, Zhang J, Spevak W, Ibrahim PN, Le MH, Hsu HH, Habets G, West BL, Bollag G, Shah NP. Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Cancer Discov. 2015 Jun;5(6):668-79. doi: 10.1158/2159-8290.CD-15-0060. Epub 2015 Apr 6. PMID: 25847190; PMCID: PMC4522415. 3: Urakami-Takebayashi Y, Kuroda Y, Murata T, Miyazaki M, Nagai J. Pioglitazone induces hypoxia-inducible factor 1 activation in human renal proximal tubular epithelial cell line HK-2. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1682-1688. doi: 10.1016/j.bbrc.2018.07.099. Epub 2018 Jul 27. PMID: 30057316. 4: Díaz-Caballero M, Navarro S, Fuentes I, Teixidor F, Ventura S. Minimalist Prion-Inspired Polar Self-Assembling Peptides. ACS Nano. 2018 Jun 26;12(6):5394-5407. doi: 10.1021/acsnano.8b00417. Epub 2018 Jun 4. PMID: 29812908. 5: Tighsazzadeh M, Mitchell JC, Boateng JS. Development and evaluation of performance characteristics of timolol-loaded composite ocular films as potential delivery platforms for treatment of glaucoma. Int J Pharm. 2019 Jul 20;566:111-125. doi: 10.1016/j.ijpharm.2019.05.059. Epub 2019 May 23. PMID: 31129346. 6: Stsiapanava A, Olsson U, Wan M, Kleinschmidt T, Rutishauser D, Zubarev RA, Samuelsson B, Rinaldo-Matthis A, Haeggström JZ. Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4227-32. doi: 10.1073/pnas.1402136111. Epub 2014 Mar 3. PMID: 24591641; PMCID: PMC3964119. 7: Acilan C, Cevatemre B, Adiguzel Z, Karakas D, Ulukaya E, Ribeiro N, Correia I, Pessoa JC. Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents. Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):218-234. doi: 10.1016/j.bbagen.2016.10.014. Epub 2016 Oct 20. PMID: 27773706. 8: Xu S, Liu J, Yang X, Qian Y, Xiao Q. Association of the DRD2 CAn-STR and DRD3 Ser9Gly polymorphisms with Parkinson's disease and response to dopamine agonists. J Neurol Sci. 2017 Jan 15;372:433-438. doi: 10.1016/j.jns.2016.08.005. Epub 2016 Aug 3. PMID: 27817855. 9: Sharma A, Suhas R, Banu SH, Chandrashekar S, Gowda DC. Implications of N-capped urea/thiourea and C-capped 3-(1-piperazinyl)-1,2-benzisothiazole with bridging Gly-Val/Phe-Gly-Val-Pro as therapeutic targets. Eur J Med Chem. 2014 Nov 24;87:657-61. doi: 10.1016/j.ejmech.2014.09.098. Epub 2014 Oct 2. PMID: 25305332. 10: Hristov G, Stankova I. Chemical stability of new acyclovir analogues with peptidomimetics. Sci Pharm. 2011 Apr-Jun;79(2):259-64. doi: 10.3797/scipharm.1012-20. Epub 2011 Mar 5. PMID: 21773064; PMCID: PMC3134859. 11: Firdaus JU, Habib A, Siddiqui N, Alam O, Naim MJ, Partap S, Sahu M. Design, synthesis, and molecular docking study of benzothiazolotriazine derivatives for anticonvulsant potential. Arch Pharm (Weinheim). 2018 Dec;351(12):e1800154. doi: 10.1002/ardp.201800154. Epub 2018 Nov 27. PMID: 30479053. 12: Eastwood EC, Eshleman AJ, Janowsky A, Phillips TJ. Verification of a genetic locus for methamphetamine intake and the impact of morphine. Mamm Genome. 2018 Apr;29(3-4):260-272. doi: 10.1007/s00335-017-9724-5. Epub 2017 Nov 10. PMID: 29127441; PMCID: PMC5889309. 13: Yakupova EI, Vikhlyantsev IM, Bobyleva LG, Penkov NV, Timchenko AA, Timchenko MA, Enin GA, Khutzian SS, Selivanova OM, Bobylev AG. Different amyloid aggregation of smooth muscles titin in vitro. J Biomol Struct Dyn. 2018 Jul;36(9):2237-2248. doi: 10.1080/07391102.2017.1348988. Epub 2017 Jul 10. PMID: 28661225. 14: Elshafie HS, Sakr SH, Sadeek SA, Camele I. Biological Investigations and Spectroscopic Studies of New Moxifloxacin/Glycine-Metal Complexes. Chem Biodivers. 2019 Mar;16(3):e1800633. doi: 10.1002/cbdv.201800633. Epub 2019 Feb 21. PMID: 30629800. 15: Ding J, Feng M, Wang F, Wang H, Guan W. Targeting effect of PEGylated liposomes modified with the Arg-Gly-Asp sequence on gastric cancer. Oncol Rep. 2015 Oct;34(4):1825-34. doi: 10.3892/or.2015.4142. Epub 2015 Jul 22. PMID: 26238930. 16: Fu P, Sun W, Lai J, Shen YH, Zhang Z. Identification of two isoforms of Pop in the domestic silkworm, Bombyx mori: Cloning, characterization and expression analysis. Gene. 2018 Aug 15;667:101-111. doi: 10.1016/j.gene.2018.05.021. Epub 2018 May 9. PMID: 29753046. 17: Bernhardt PV, Comba P, Fairlie DP, Gahan LR, Hanson GR, Lötzbeyer L. Synthesis and structural properties of patellamide A derivatives and their copper(II) compounds. Chemistry. 2002 Apr 2;8(7):1527-36. doi: 10.1002/1521-3765(20020402)8:7<1527::aid-chem1527>3.0.co;2-f. PMID: 11921237. 18: Asano A, Doi M. The desoxazoline asidiacyclamide analogue cyclo(Gly-Thr-D- Val-Thz-Ile-Thr-D-Val-Thz) acetonitrile monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2012 Jan;68(Pt 1):o54-5. doi: 10.1107/S1600536811051543. Epub 2011 Dec 10. PMID: 22259556; PMCID: PMC3254412. 19: Gao WW, Gopala L, Bheemanaboina RRY, Zhang GB, Li S, Zhou CH. Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii. Eur J Med Chem. 2018 Feb 25;146:15-37. doi: 10.1016/j.ejmech.2018.01.038. Epub 2018 Jan 12. PMID: 29396362. 20: Chibisa GE, Vinyard JR, Laarman AH. Short communication: Effects of meloxicam administration on protein metabolism and growth performance in transported Jersey calves. J Dairy Sci. 2018 Dec;101(12):11435-11440. doi: 10.3168/jds.2018-14493. Epub 2018 Sep 27. PMID: 30268623.