MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 591861 | Name: Lawsone
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lawsone, also known as Naphaquinon, is a molluscacide from leaves of Lawsonia inermis L. topical sunscreening agent; powdered leaves of Lawsonia inermis(Lythraceae) used as brown hair dye.

Chemical Structure

Lawsone
Lawsone
CAS#83-72-7

Theoretical Analysis

MedKoo Cat#: 591861

Name: Lawsone

CAS#: 83-72-7

Chemical Formula: C10H6O3

Exact Mass: 174.0317

Molecular Weight: 174.16

Elemental Analysis: C, 68.97; H, 3.47; O, 27.56

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 450.00 2 Weeks
100g USD 750.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Lawsone; Naphaquinone;
IUPAC/Chemical Name
1,4-Naphthalenedione, 2-hydroxy-
InChi Key
CSFWPUWCSPOLJW-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H6O3/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5,12H
SMILES Code
O=C1C(O)=CC(C2=C1C=CC=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Lawsone is a naphthoquinone dye isolated from leaves of Lawsonia inermis that shows antimicrobial and antioxidant activity.
In vitro activity:
Lawsone affected yeast growth in glycerol, indicating interference in the respiratory metabolism. By analysing the sensitivity of atg mutant strains and the localization of GFP-Atg8 fusion protein, it was concluded that lawsone primarily produces mitochondrial malfunctioning, leading to indirect oxidative stress. Reference: Mol Biol Rep. 2020 Feb;47(2):1173-1185. https://pubmed.ncbi.nlm.nih.gov/31811499/
In vivo activity:
In skin regeneration models, Lawsone interferes with physiological tissue regeneration and inhibits wound healing. Conversely, in a human acute dermatitis model, topical application of a Lawsone-containing cream ameliorates skin irritation. Reference: Sci Rep. 2019 Jul 26;9(1):10878. https://pubmed.ncbi.nlm.nih.gov/31350436/
Solvent mg/mL mM comments
Solubility
DMSO 67.0 384.71
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 174.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Xavier MR, Santos MMS, Queiroz MG, de Lima Silva MS, Goes AJS, De Morais MA Jr. Lawsone, a 2-hydroxy-1,4-naphthoquinone from Lawsonia inermis (henna), produces mitochondrial dysfunctions and triggers mitophagy in Saccharomyces cerevisiae. Mol Biol Rep. 2020 Feb;47(2):1173-1185. doi: 10.1007/s11033-019-05218-3. Epub 2019 Dec 6. PMID: 31811499. 2. Tripathi RD, Srivastava HS, Dixit SN. A fungitoxic principle from the leaves of lawsonia inermis lam. Experientia. 1978 Jan 15;34(1):51-2. doi: 10.1007/BF01921895. PMID: 620734. 3. Lozza L, Moura-Alves P, Domaszewska T, Lage Crespo C, Streata I, Kreuchwig A, Puyskens A, Bechtle M, Klemm M, Zedler U, Silviu Ungureanu B, Guhlich-Bornhof U, Koehler AB, Stäber M, Mollenkopf HJ, Hurwitz R, Furkert J, Krause G, Weiner J 3rd, Jacinto A, Mihai I, Leite-de-Moraes M, Siebenhaar F, Maurer M, Kaufmann SHE. The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis. Sci Rep. 2019 Jul 26;9(1):10878. doi: 10.1038/s41598-019-47350-x. Erratum in: Sci Rep. 2020 May 20;10(1):8640. PMID: 31350436; PMCID: PMC6659674. 4. Wang SB, Tao Z, Li P. Lawsone suppresses azoxymethane mediated colon cancer in rats and reduces proliferation of DLD-1 cells via NF-κB pathway. Biomed Pharmacother. 2017 May;89:152-161. doi: 10.1016/j.biopha.2017.01.169. Epub 2017 Feb 20. PMID: 28222396.
In vitro protocol:
1. Xavier MR, Santos MMS, Queiroz MG, de Lima Silva MS, Goes AJS, De Morais MA Jr. Lawsone, a 2-hydroxy-1,4-naphthoquinone from Lawsonia inermis (henna), produces mitochondrial dysfunctions and triggers mitophagy in Saccharomyces cerevisiae. Mol Biol Rep. 2020 Feb;47(2):1173-1185. doi: 10.1007/s11033-019-05218-3. Epub 2019 Dec 6. PMID: 31811499. 2. Tripathi RD, Srivastava HS, Dixit SN. A fungitoxic principle from the leaves of lawsonia inermis lam. Experientia. 1978 Jan 15;34(1):51-2. doi: 10.1007/BF01921895. PMID: 620734.
In vivo protocol:
1. Lozza L, Moura-Alves P, Domaszewska T, Lage Crespo C, Streata I, Kreuchwig A, Puyskens A, Bechtle M, Klemm M, Zedler U, Silviu Ungureanu B, Guhlich-Bornhof U, Koehler AB, Stäber M, Mollenkopf HJ, Hurwitz R, Furkert J, Krause G, Weiner J 3rd, Jacinto A, Mihai I, Leite-de-Moraes M, Siebenhaar F, Maurer M, Kaufmann SHE. The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis. Sci Rep. 2019 Jul 26;9(1):10878. doi: 10.1038/s41598-019-47350-x. Erratum in: Sci Rep. 2020 May 20;10(1):8640. PMID: 31350436; PMCID: PMC6659674. 2. Wang SB, Tao Z, Li P. Lawsone suppresses azoxymethane mediated colon cancer in rats and reduces proliferation of DLD-1 cells via NF-κB pathway. Biomed Pharmacother. 2017 May;89:152-161. doi: 10.1016/j.biopha.2017.01.169. Epub 2017 Feb 20. PMID: 28222396.

View History

SC-50998

SC-50998

SC 67655

SC 67655

Distamycin 2

Distamycin 2