DS1 is a small molecule that selectively enhances the activity of extrasynaptic GABAA receptors containing the δ-subunit, without significantly affecting synaptic GABA<sub>A</sub> receptors. It acts as a positive allosteric modulator, potentiating tonic inhibitory currents in the brain and offering potential therapeutic utility in disorders involving hyperexcitability, such as epilepsy or anxiety. DS1 exhibits high selectivity and potency, making it a valuable pharmacological tool for studying the role of δ-containing GABAA receptors in CNS function.
MedKoo Cat#: 574347
Name: DS1
CAS#: 372497-52-4
Chemical Formula: C18H10Br2ClN3OS
Exact Mass: 508.8600
Molecular Weight: 511.62
Elemental Analysis: C, 42.26; H, 1.97; Br, 31.24; Cl, 6.93; N, 8.21; O, 3.13; S, 6.27
The following data is based on the product molecular weight 511.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
