DS79932728 is a Potent, Orally Available G9a/GLP Inhibitor for Treating β‑Thalassemia and Sickle Cell Disease. DS79932728 was found to induce γ-globin production in a phlebotomized cynomolgus monkey model. DS79932728 showed excellent metabolic stability in monkeys. In the in vivo phlebotomized cynomolgus monkey model, DS79932728, showed γ-globin induction at 15 mg/kg p.o., and the effect of DS79932728 on HbF levels appeared to be comparable to that of HU.
MedKoo Cat#: 463699
Name: DS79932728
CAS#: 2757191-62-9
Chemical Formula: C19H25N3O
Exact Mass: 311.1998
Molecular Weight: 311.43
Elemental Analysis: C, 73.28; H, 8.09; N, 13.49; O, 5.14
The following data is based on the product molecular weight 311.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
