NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB-598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB-598 suppressed the basolateral secretion of apolipoprotein (apo) B. When microsomes prepared from control Caco-2 cells were incubated with 10 microM NB-598, acyl CoA:cholesterol acyltransferase (ACAT) activity was inhibited slightly.
MedKoo Cat#: 555800
Name: NB-598 free base
CAS#: 131060-14-5 (free base)
Chemical Formula: C27H31NOS2
Exact Mass: 449.1847
Molecular Weight: 449.67
Elemental Analysis: C, 72.12; H, 6.95; N, 3.11; O, 3.56; S, 14.26
Solvent | mg/mL | mM | |
---|---|---|---|
Solubility | |||
DMSO | 90.0 | 200.15 | |
Ethanol | 10.0 | 22.24 |
The following data is based on the product molecular weight 449.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |