Azemiglitazone sodium | CAS#1314533-26-0 | insulin sensitizer

MedKoo Cat#: 534799 | Name: Azemiglitazone sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes (metabolic modulator).

Chemical Structure

Azemiglitazone sodium

CAS#1314533-26-0 (sodium)

Theoretical Analysis

MedKoo Cat#: 534799

Name: Azemiglitazone sodium

CAS#: 1314533-26-0 (sodium)

Chemical Formula: C19H16NNaO5S

Exact Mass: 393.0647

Molecular Weight: 393.39

Elemental Analysis: C, 58.01; H, 4.10; N, 3.56; Na, 5.84; O, 20.33; S, 8.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1133819-87-0 (free base) 1314533-26-0 (sodium) 1314533-27-1 (potassium)

Synonym

Azemiglitazone sodium

IUPAC/Chemical Name

2,4-Thiazolidinedione, 5-((4-(2-(3-methoxyphenyl)-2-oxoethoxy)phenyl)methyl)-, sodium salt (1:1)

InChi Key

OZJDMAGRSNXUOZ-UHFFFAOYSA-M

InChi Code

InChI=1S/C19H17NO5S.Na/c1-24-15-4-2-3-13(10-15)16(21)11-25-14-7-5-12(6-8-14)9-17-18(22)20-19(23)26-17;/h2-8,10,17H,9,11H2,1H3,(H,20,22,23);/q;+1/p-1

SMILES Code

O=C([N-]1)SC(CC2=CC=C(OCC(C3=CC=CC(OC)=C3)=O)C=C2)C1=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 393.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: O'Donnell M, Mann JF, Schutte AE, Staessen JA, Lopez-Jaramillo P, Thomas M, Mente A, Saulnier PJ, Yusuf S. Dietary Sodium and Cardiovascular Disease Risk. N Engl J Med. 2016 Dec 15;375(24):2404-2406. doi: 10.1056/NEJMc1612304. PMID: 27974028. 2: Adrogué HJ, Madias NE. Sodium and potassium in the pathogenesis of hypertension. N Engl J Med. 2007 May 10;356(19):1966-78. doi: 10.1056/NEJMra064486. PMID: 17494929. 3: Mizéhoun-Adissoda C, Houinato D, Houehanou C, Chianea T, Dalmay F, Bigot A, Aboyans V, Preux PM, Bovet P, Desport JC. Dietary sodium and potassium intakes: Data from urban and rural areas. Nutrition. 2017 Jan;33:35-41. doi: 10.1016/j.nut.2016.08.007. Epub 2016 Sep 7. PMID: 27908548. 4: Spineti PPM. Evaluating Sodium Restriction in Heart Failure. Arq Bras Cardiol. 2019 Feb;112(2):171-172. doi: 10.5935/abc.20190017. PMID: 30785582; PMCID: PMC6371825. 5: Cogswell ME, Loria CM, Appel LJ. Sodium Excretion in Population Subgroups- Reply. JAMA. 2018 Aug 21;320(7):720. doi: 10.1001/jama.2018.8028. PMID: 30140874. 6: Jürgens G. Sodium Excretion in Population Subgroups. JAMA. 2018 Aug 21;320(7):719-720. doi: 10.1001/jama.2018.8012. PMID: 30140871. 7: Salvi P, Giannattasio C, Parati G. High sodium intake and arterial stiffness. J Hypertens. 2018 Apr;36(4):754-758. doi: 10.1097/HJH.0000000000001658. PMID: 29489612. 8: Turner MJ, Avolio AP. Does Replacing Sodium Excreted in Sweat Attenuate the Health Benefits of Physical Activity? Int J Sport Nutr Exerc Metab. 2016 Aug;26(4):377-89. doi: 10.1123/ijsnem.2015-0233. Epub 2016 Feb 3. PMID: 26841436. 9: Yee J. Hypertension in CKD: Sodium still at the nexus. Adv Chronic Kidney Dis. 2015 May;22(3):173-6. doi: 10.1053/j.ackd.2015.03.004. PMID: 25908464. 10: Wei L, Mackenzie IS, MacDonald TM, George J. Cardiovascular risk associated with sodium-containing medicines. Expert Opin Drug Saf. 2014 Nov;13(11):1515-23. doi: 10.1517/14740338.2014.970163. Epub 2014 Oct 10. PMID: 25300906. 11: McCaughey SA, Scott TR. The taste of sodium. Neurosci Biobehav Rev. 1998 Sep;22(5):663-76. doi: 10.1016/s0149-7634(97)00067-5. PMID: 9662727. 12: Uechi K, Sugimoto M, Kobayashi S, Sasaki S. Urine 24-Hour Sodium Excretion Decreased between 1953 and 2014 in Japan, but Estimated Intake Still Exceeds the WHO Recommendation. J Nutr. 2017 Mar;147(3):390-397. doi: 10.3945/jn.116.240960. Epub 2017 Jan 18. PMID: 28100605. 13: McCarron DA, Alderman MH. Reducing Sodium Intake in the Population. JAMA. 2016 Dec 20;316(23):2550. doi: 10.1001/jama.2016.16100. PMID: 27997645. 14: Frieden TR. Reducing Sodium Intake in the Population-Reply. JAMA. 2016 Dec 20;316(23):2550-2551. doi: 10.1001/jama.2016.16106. PMID: 27997649. 15: Cogswell ME, Frieden TR. Dietary Sodium and Cardiovascular Disease Risk. N Engl J Med. 2016 Dec 15;375(24):2407-2408. doi: 10.1056/NEJMc1612304. PMID: 27974027; PMCID: PMC5381718. 16: Johns DM. Dietary Sodium and Cardiovascular Disease Risk. N Engl J Med. 2016 Dec 15;375(24):2407. doi: 10.1056/NEJMc1612304. PMID: 28032971. 17: Graudal N. Dietary Sodium and Cardiovascular Disease Risk. N Engl J Med. 2016 Dec 15;375(24):2406-7. doi: 10.1056/NEJMc1612304. PMID: 28032970. 18: Alderman MH. Dietary Sodium and Cardiovascular Disease Risk. N Engl J Med. 2016 Dec 15;375(24):2406. doi: 10.1056/NEJMc1612304. PMID: 28032969. 19: Li CL, Wang HJ, Si QJ, Zhou J, Li KL, Ding Y. Association between urinary sodium excretion and coronary heart disease in hospitalized elderly patients in China. J Int Med Res. 2018 Aug;46(8):3078-3085. doi: 10.1177/0300060518772222. Epub 2018 May 13. PMID: 29756493; PMCID: PMC6134650. 20: Fatahi S, Namazi N, Larijani B, Azadbakht L. The Association of Dietary and Urinary Sodium With Bone Mineral Density and Risk of Osteoporosis: A Systematic Review and Meta-Analysis. J Am Coll Nutr. 2018 Aug;37(6):522-532. doi: 10.1080/07315724.2018.1431161. Epub 2018 Apr 4. PMID: 29617220.