MedKoo Cat#: 462131 | Name: CAY10760
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2. It decreases homologous recombination by 54% in wild-type BRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM.

Chemical Structure

CAY10760
CAY10760
CAS#391889-85-3

Theoretical Analysis

MedKoo Cat#: 462131

Name: CAY10760

CAS#: 391889-85-3

Chemical Formula: C28H24ClN3O3

Exact Mass: 485.1506

Molecular Weight: 485.97

Elemental Analysis: C, 69.20; H, 4.98; Cl, 7.29; N, 8.65; O, 9.88

Price and Availability

Size Price Availability Quantity
5mg USD 485.00 2 Weeks
10mg USD 850.00 2 Weeks
25mg USD 1,450.00 2 Weeks
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Related CAS #
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Synonym
CAY10760; CAY 10760; CAY-10760; Homologous recombination-IN-1
IUPAC/Chemical Name
6-chloro-3-[4,5-dihydro-5-(4-methoxyphenyl)-1-(1-oxopropyl)-1H-pyrazol-3-yl]-4-phenyl-2(1H)-quinolinone
InChi Key
LAVOKBSCOSIGER-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H24ClN3O3/c1-3-25(33)32-24(17-9-12-20(35-2)13-10-17)16-23(31-32)27-26(18-7-5-4-6-8-18)21-15-19(29)11-14-22(21)30-28(27)34/h4-15,24H,3,16H2,1-2H3,(H,30,34)
SMILES Code
O=C1NC2=C(C=C(Cl)C=C2)C(C3=CC=CC=C3)=C1C4=NN(C(CC)=O)C(C5=CC=C(OC)C=C5)C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 485.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bagnolini, G., Milano, D., Manerba, M., et al. Synthetic lethality in pancreatic cancer: Discovery of a new RAD51-BRCA2 small molecule disruptor that inhibits homologous recombination and synergizes with olaparib. J. Med. Chem. 63(5), 2588-2619 (2020).