MedKoo Cat#: 593190 | Name: DSM43

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target for malaria treatmen

Chemical Structure

DSM43
DSM43
CAS#32542-16-8

Theoretical Analysis

MedKoo Cat#: 593190

Name: DSM43

CAS#: 32542-16-8

Chemical Formula: C18H23NO3

Exact Mass: 301.1678

Molecular Weight: 301.39

Elemental Analysis: C, 71.73; H, 7.69; N, 4.65; O, 15.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DSM43; DSM-43; DSM 43
IUPAC/Chemical Name
Ethyl 4-(4-Ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
InChi Key
AHTZIFIBNCSFEG-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H23NO3/c1-5-21-15-9-7-14(8-10-15)11-16-12(3)17(19-13(16)4)18(20)22-6-2/h7-10,19H,5-6,11H2,1-4H3
SMILES Code
O=C(C1=C(C)C(CC2=CC=C(OCC)C=C2)=C(C)N1)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Malaria puts at risk nearly half the world’s population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target for malaria treatment based on our finding that triazolopyrimidine DSM265 showed efficacy in clinical studies

Preparing Stock Solutions

The following data is based on the product molecular weight 301.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Kokkonda S, Deng X, White KL, et al. Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria [published online ahead of print, 2020 Apr 16]. J Med Chem. 2020;10.1021/acs.jmedchem.0c00311. doi:10.1021/acs.jmedchem.0c00311