Synonym
Gastrodin; Gastrodine;
IUPAC/Chemical Name
4-(hydroxymethyl)phenyl β-D-glucopyranoside
InChi Key
PUQSUZTXKPLAPR-UJPOAAIJSA-N
InChi Code
InChI=1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1
SMILES Code
O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(CO)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects.
In vitro activity:
Treatment with gastrodin attenuated H2O2-induced ferroptosis and decreased lipid reactive oxygen species (ROS) (C11-BODIPY)
production in C6 cells. Moreover, gastrodin increased the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2),
GPX4, ferroportin-1 (FPN1), and heme oxygenase-1 (HO-1) in C6 cells treated with H2O2.
Reference: Biol Pharm Bull. 2020;43(3):480-487. https://pubmed.ncbi.nlm.nih.gov/32115506/
In vivo activity:
Intraperitoneal injection with gastrodin 10 mg/kg or 50 mg/kg once daily for 15d significantly inhibited the loss of RGCs because of
AOH damage (Figure 1D, 1E). Compared to the NS group, the density of the RGCs increased to 937.4±141.7 cells/mm2
and
1031±179.2 cells/mm2
, respectively (Figure 1F). These results indicated that systemic gastrodin had a neuroprotective effect on RGCs
in the AOH animal model.
Reference: Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489. https://pubmed.ncbi.nlm.nih.gov/29062764/
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
30.0 |
104.79 |
| DMSO |
60.0 |
209.59 |
| PBS (pH 7.2) |
5.0 |
17.47 |
| Water |
100.0 |
349.31 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
286.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Li S, Yang Q, Zhou Z, Yang X, Liu Y, Hao K, Fu M. Gastrodin protects retinal ganglion cells from ischemic injury by activating
phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway.
Bioengineered. 2022 May;13(5):12625-12636. doi: 10.1080/21655979.2022.2076499. PMID: 35609324; PMCID: PMC9275977.
2. Jiang T, Chu J, Chen H, Cheng H, Su J, Wang X, Cao Y, Tian S, Li Q. Gastrodin Inhibits H2O2-Induced Ferroptosis through Its
Antioxidative Effect in Rat Glioma Cell Line C6. Biol Pharm Bull. 2020;43(3):480-487. doi: 10.1248/bpb.b19-00824. PMID:
32115506.
3. Fasina OB, Wang J, Mo J, Osada H, Ohno H, Pan W, Xiang L, Qi J. Gastrodin From Gastrodia elata Enhances Cognitive Function
and Neuroprotection of AD Mice via the Regulation of Gut Microbiota Composition and Inhibition of Neuron Inflammation. Front
Pharmacol. 2022 Jun 2;13:814271. doi: 10.3389/fphar.2022.814271. PMID: 35721206; PMCID: PMC9201506.
4. Wang JW, Liu YM, Zhao XF, Zhang H. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated
neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489. doi:
10.18240/ijo.2017.10.01. PMID: 29062764; PMCID: PMC5638966.
In vitro protocol:
1. Li S, Yang Q, Zhou Z, Yang X, Liu Y, Hao K, Fu M. Gastrodin protects retinal ganglion cells from ischemic injury by activating
phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway.
Bioengineered. 2022 May;13(5):12625-12636. doi: 10.1080/21655979.2022.2076499. PMID: 35609324; PMCID: PMC9275977.
2. Jiang T, Chu J, Chen H, Cheng H, Su J, Wang X, Cao Y, Tian S, Li Q. Gastrodin Inhibits H2O2-Induced Ferroptosis through Its
Antioxidative Effect in Rat Glioma Cell Line C6. Biol Pharm Bull. 2020;43(3):480-487. doi: 10.1248/bpb.b19-00824. PMID:
32115506.
In vivo protocol:
1. Fasina OB, Wang J, Mo J, Osada H, Ohno H, Pan W, Xiang L, Qi J. Gastrodin From Gastrodia elata Enhances Cognitive Function
and Neuroprotection of AD Mice via the Regulation of Gut Microbiota Composition and Inhibition of Neuron Inflammation. Front
Pharmacol. 2022 Jun 2;13:814271. doi: 10.3389/fphar.2022.814271. PMID: 35721206; PMCID: PMC9201506.
2. Wang JW, Liu YM, Zhao XF, Zhang H. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated
neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489. doi:
10.18240/ijo.2017.10.01. PMID: 29062764; PMCID: PMC5638966.
1. Liu, Y., Gao, J., Peng, M., et al. A review on central nervous system effects of gastrodin. Front. Pharmacol. 9:24, (2018).
2. Wang, X., Tao, J., Qiao, Y., et al. Gastrodin rescues autistic-like phenotypes in valproic acid-induced animal model. Front. Neurol. 9:1052, (2018).
3. Liu, S., Zhou, L., Yang, L., et al. Gastrodin alleviates glucocorticoid induced osteoporosis in rats via activating the Nrf2 signaling pathways. Oncotarget 9(14), 11528-11540 (2018).
4. Zhang, Y., Wang, C., Yu, B., et al. Gastrodin protects against ethanol-induced liver injury and apoptosis in HepG2 cells and animal models of alcoholic liver disease. Biol. Pharm. Bull. 41(5), 670-679 (2018).
