DSP-2230 | CAS# 1233231-30-5 | Nav1.7/8 Blocker

MedKoo Cat#: 564675 | Name: DSP-2230

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DSP-2230 is a selective Nav1.7/Nav1.8 blocker.

Chemical Structure

DSP-2230

CAS#1233231-30-5

Theoretical Analysis

MedKoo Cat#: 564675

Name: DSP-2230

CAS#: 1233231-30-5

Chemical Formula: C20H20F3N5O2

Exact Mass: 419.1569

Molecular Weight: 419.41

Elemental Analysis: C, 57.28; H, 4.81; F, 13.59; N, 16.70; O, 7.63

Price and Availability

Size	Price	Availability
5mg	USD 110.00	Ready to ship
10mg	USD 180.00	Ready to ship
25mg	USD 385.00	Ready to ship
50mg	USD 650.00	Ready to ship
100mg	USD 1,050.00	Ready to ship
200mg	USD 1,750.00	Ready to ship
500mg	USD 3,050.00	Ready to ship

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Related CAS #

No Data

Synonym

DSP2230; DSP 2230; DSP-2230

IUPAC/Chemical Name

(R)-2-(((3-Cyclobutyl-5-(3,4,5-trifluorophenoxy)-3H-imidazo[4,5-b]pyridin-2-yl)methyl)amino)propanamide

InChi Key

HHXCJIMPEJSJTG-SNVBAGLBSA-N

InChi Code

InChI=1S/C20H20F3N5O2/c1-10(19(24)29)25-9-16-26-15-5-6-17(27-20(15)28(16)11-3-2-4-11)30-12-7-13(21)18(23)14(22)8-12/h5-8,10-11,25H,2-4,9H2,1H3,(H2,24,29)/t10-/m1/s1

SMILES Code

C[C@@H](NCC1=NC2=CC=C(OC3=CC(F)=C(F)C(F)=C3)N=C2N1C4CCC4)C(N)=O

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#A20T05K21

QC Data

View QC data: current batch, Lot#A20T05K21

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

DSP-2230 is a selective Nav1.7/Nav1.8 blocker.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	125.0	298.04

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 419.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1. Bagal SK, Marron BE, Owen RM, Storer RI, Swain NA. Voltage gated sodium channels as drug discovery targets. Channels (Austin). 2015;9(6):360-6. doi: 10.1080/19336950.2015.1079674. PMID: 26646477; PMCID: PMC4850042. 2. Alsaloum M, Higerd GP, Effraim PR, Waxman SG. Status of peripheral sodium channel blockers for non-addictive pain treatment. Nat Rev Neurol. 2020 Dec;16(12):689-705. doi: 10.1038/s41582-020-00415-2. Epub 2020 Oct 27. PMID: 33110213. 3. Sara Sabina Hadida-Ruah, et al. Sulfonamides as modulators of sodium channels. https://patents.google.com/patent/WO2015010065A1