MedKoo Cat#: 555767 | Name: CIN16645
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CIN16645, also known as LP-01 lipid, is an ionizable lipid, IT is useful in lipid nanopparticle formulation for DNA and RNA vaccine delivery and Gene editing. CIN16645 was first reported in Novartis patent WO 2015095340A1. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming)..

Chemical Structure

CIN16645
CIN16645
CAS#1799316-64-5 (free base)

Theoretical Analysis

MedKoo Cat#: 555767

Name: CIN16645

CAS#: 1799316-64-5 (free base)

Chemical Formula: C50H93NO9

Exact Mass: 851.6850

Molecular Weight: 852.29

Elemental Analysis: C, 70.46; H, 11.00; N, 1.64; O, 16.89

Price and Availability

Size Price Availability Quantity
5mg USD 150.00 Ready to ship
10mg USD 250.00 Ready to ship
25mg USD 450.00 Ready to ship
50mg USD 750.00 Ready to ship
100mg USD 1,250.00 Ready to ship
200mg USD 1,950.00 Ready to ship
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Synonym
CIN-16645; CIN 16645; CIN16645; LP-01 lipid;
IUPAC/Chemical Name
3-((4,4-bis(octyloxy)butanoyl)oxy)-2-((((3-(diethylamino)propoxy)carbonyl)oxy)methyl)propyl (9Z,12Z)-octadeca-9,12-dienoate
InChi Key
CHTXXFZHKGGQGX-IFLFXUNCSA-N
InChi Code
InChI=1S/C50H93NO9/c1-6-11-14-17-20-21-22-23-24-25-26-27-28-29-32-36-47(52)58-43-46(45-60-50(54)57-42-35-39-51(9-4)10-5)44-59-48(53)37-38-49(55-40-33-30-18-15-12-7-2)56-41-34-31-19-16-13-8-3/h20-21,23-24,46,49H,6-19,22,25-45H2,1-5H3/b21-20-,24-23-
SMILES Code
CCCCC/C=C\C/C=C\CCCCCCCC(OCC(COC(OCCCN(CC)CC)=O)COC(CCC(OCCCCCCCC)OCCCCCCCC)=O)=O
Appearance
Oily Liquid (Lipid)
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
CIN-16645 is a cationic lipid and is useful in the delivery of biologically active agents to cells and tissues.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 852.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. Brito, Luis; Chen, Delai; Gamber, Gabriel Grant; Geall, Andrew; Love, Kevin; Zabawa, Thomas; Zecri, Frederic (Novartis AG, Switz.). WO2015095340A1 2. Morrissey, David V.; Patel, Mihir Chandrakant; Finn, Jonathan D.; Smith, Amy Madison Rhoden; Shaw, Lucinda J.; Dombrowski, Christian; Shah, Ruchi Rudraprasad (Assignee: Intellia Therapeutics, Inc., USA), Lipid nanoparticle formulations for CRISPR​/Cas components, WO 2017173054.