MedKoo Cat#: 555740 | Name: TUG-1907

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TUG-1907 is a Free Fatty Acid Receptor 3 (FFA3) Modulator with EC50 = 145 nM and a solubility of 33 μM, showed high clearance in vivo but is a preferred tool in vitro.

Chemical Structure

TUG-1907
TUG-1907
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 555740

Name: TUG-1907

CAS#: N/A

Chemical Formula: C20H22Cl2N2O2

Exact Mass: 392.1058

Molecular Weight: 393.31

Elemental Analysis: C, 61.08; H, 5.64; Cl, 18.03; N, 7.12; O, 8.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TUG-1907; TUG 1907; TUG1907;
IUPAC/Chemical Name
N-(2,5-Dichlorophenyl)-2-methyl-5-oxo-4-propyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
InChi Key
IIXZJMYGKNKDGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H22Cl2N2O2/c1-3-5-13-18(11(2)23-15-6-4-7-17(25)19(13)15)20(26)24-16-10-12(21)8-9-14(16)22/h8-10,13,23H,3-7H2,1-2H3,(H,24,26)
SMILES Code
O=C(C1=C(C)NC2=C(C(CCC2)=O)C1CCC)NC3=CC(Cl)=CC=C3Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Free fatty acid receptor 3 (FFA3, previously GPR41) is activated by short-chain fatty acids, mediates health effects of the gut microbiota, and is a therapeutic target for metabolic and inflammatory diseases. The shortage of wellcharacterized tool compounds has however impeded progress.

Preparing Stock Solutions

The following data is based on the product molecular weight 393.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Structure–Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators Elisabeth Rexen Ulven*Tezz QuonEugenia SergeevNatasja BarkiMatjaz BrvarBrian D. HudsonPalash DuttaAnders Højgaard HansenLine Ø. BielefeldtAndrew B. TobinChristine J. McKenzieGraeme MilliganTrond Ulven Journal of Medicinal Chemistry, Articles ASAP (Article) Publication Date (Web):March 6, 2020