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MedKoo Cat#: 534858 | Name: Mycophenolate sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mycophenolate sodium is an immunosuppressant.

Chemical Structure

Mycophenolate sodium
Mycophenolate sodium
CAS#37415-62-6 (sodium)

Theoretical Analysis

MedKoo Cat#: 534858

Name: Mycophenolate sodium

CAS#: 37415-62-6 (sodium)

Chemical Formula: C17H19NaO6

Exact Mass: 342.1079

Molecular Weight: 342.32

Elemental Analysis: C, 59.65; H, 5.59; Na, 6.72; O, 28.04

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
100mg USD 550.00 2 Weeks
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Related CAS #
24280-93-1 (free acid) 66341-85-3 (triethylamine) 37415-62-6 (sodium)
Synonym
Mycophenolate sodium
IUPAC/Chemical Name
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, monosodium salt, (4E)-
InChi Key
DOZYTHNHLLSNIK-JOKMOOFLSA-M
InChi Code
InChI=1S/C17H20O6.Na/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3;/h4,20H,5-8H2,1-3H3,(H,18,19);/q;+1/p-1/b9-4+;
SMILES Code
O=C([O-])CC/C(C)=C/CC1=C(O)C2=C(COC2=O)C(C)=C1OC.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 342.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: van Gelder T, Hesselink DA. Mycophenolate revisited. Transpl Int. 2015 May;28(5):508-15. doi: 10.1111/tri.12554. PMID: 25758949. 2: Hiramoto LL, Tedesco-Silva H, Medina-Pestana JO, Felipe CR. Tolerability of mycophenolate sodium in renal transplant recipients. Int J Clin Pharm. 2018 Dec;40(6):1548-1558. doi: 10.1007/s11096-018-0727-4. Epub 2018 Oct 9. PMID: 30302621. 3: Staatz CE, Tett SE. Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients. Clin Pharmacokinet. 2007;46(1):13-58. doi: 10.2165/00003088-200746010-00002. PMID: 17201457. 4: Gabardi S, Tran JL, Clarkson MR. Enteric-coated mycophenolate sodium. Ann Pharmacother. 2003 Nov;37(11):1685-93. doi: 10.1345/aph.1D063. PMID: 14565799. 5: Budde K, Dürr M, Liefeldt L, Neumayer HH, Glander P. Enteric-coated mycophenolate sodium. Expert Opin Drug Saf. 2010 Nov;9(6):981-94. doi: 10.1517/14740338.2010.513379. PMID: 20795786. 6: Curran MP, Keating GM. Mycophenolate sodium delayed release: prevention of renal transplant rejection. Drugs. 2005;65(6):799-805; discussion 806-7. doi: 10.2165/00003495-200565060-00007. PMID: 15819592. 7: Isidori A, Loscocco F, Malerba L, Clissa C, Guiducci B, Visani G. Enteric- coated mycophenolate sodium: a new option for GHVD prophylaxis? Eur J Haematol. 2017 Apr;98(4):320-321. doi: 10.1111/ejh.12739. PMID: 26800509. 8: Ingle GR, Shah T. Enteric-coated mycophenolate sodium for transplant immunosuppression. Am J Health Syst Pharm. 2005 Nov 1;62(21):2252-9. doi: 10.2146/ajhp040380. Erratum in: Am J Health Syst Pharm. 2006 Mar 15;63(6):492. PMID: 16239415. 9: Midtvedt K, Bergan S, Reisæter AV, Vikse BE, Åsberg A. Exposure to Mycophenolate and Fatherhood. Transplantation. 2017 Jul;101(7):e214-e217. doi: 10.1097/TP.0000000000001747. PMID: 28346297; PMCID: PMC5482562. 10: Lazarevic VLj. Enteric-coated mycophenolate sodium could be an alternative to methotrexate for GVHD prophylaxis. Eur J Haematol. 2016 Sep;97(3):213-4. doi: 10.1111/ejh.12727. PMID: 26712567. 11: Sanford M, Keating GM. Enteric-coated mycophenolate sodium: a review of its use in the prevention of renal transplant rejection. Drugs. 2008;68(17):2505-33. doi: 10.2165/0003495-200868170-00007. PMID: 19016576. 12: Qureshi A, Scheinfeld N. Myfortic (mycophenolate sodium) delayed-release tablets. Dermatol Online J. 2008 Aug 15;14(8):4. PMID: 19061564. 13: Behrend M, Braun F. Enteric-coated mycophenolate sodium: tolerability profile compared with mycophenolate mofetil. Drugs. 2005;65(8):1037-50. doi: 10.2165/00003495-200565080-00001. PMID: 15907141. 14: Gardiner KM, Tett SE, Staatz CE. Is Conversion from Mycophenolate Mofetil to Enteric-Coated Mycophenolate Sodium Justifiable for Gastrointestinal Quality of Life? Drugs R D. 2018 Dec;18(4):271-282. doi: 10.1007/s40268-018-0254-8. PMID: 30426342; PMCID: PMC6277323. 15: Doukaki S, Platamone A, Alaimo R, Bongiorno MR. Mycophenolate mofetil and enteric-coated mycophenolate sodium in the treatment of pemphigus vulgaris and pemphigus foliaceus. J Dermatolog Treat. 2015 Feb;26(1):67-72. doi: 10.3109/09546634.2014.880395. Epub 2014 Feb 13. PMID: 24521072. 16: Kapoor K, Saha A, Kaur M, Dubey NK, Upadhyay AD. Mycophenolate Sodium for Children with Frequently Relapsing or Steroid Dependent Nephrotic Syndrome. Indian Pediatr. 2017 Oct 15;54(10):885-886. doi: 10.1007/s13312-017-1156-5. PMID: 29120340. 17: Zhang W, Ding C, Zheng S. Enteric-coated mycophenolate sodium: an update. Int J Clin Pract Suppl. 2014 Apr;(181):1-3. doi: 10.1111/ijcp.12399. PMID: 24673712. 18: Filler G, Buffo I. Safety considerations with mycophenolate sodium. Expert Opin Drug Saf. 2007 Jul;6(4):445-9. doi: 10.1517/14740338.6.4.445. PMID: 17688388. 19: Cooper M, Salvadori M, Budde K, Oppenheimer F, Sollinger H, Zeier M. Enteric-coated mycophenolate sodium immunosuppression in renal transplant patients: efficacy and dosing. Transplant Rev (Orlando). 2012 Oct;26(4):233-40. doi: 10.1016/j.trre.2012.02.001. Epub 2012 Aug 3. PMID: 22863029. 20: Doycheva D, Zierhut M, Blumenstock G, Sobolewska B, Voykov B, Hohmann J, Spitzer MS, Deuter C. Mycophenolate sodium for the treatment of chronic non- infectious uveitis of childhood. Br J Ophthalmol. 2016 Aug;100(8):1071-5. doi: 10.1136/bjophthalmol-2015-306701. Epub 2015 Nov 13. PMID: 26567021.