MedKoo Cat#: 533896 | Name: WIC1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

WIC1 is a novel potent Wnt inhibitor, promoting airway basal stem cell homeostasis, acting to repress phosphorylation of β-cateninY489 and Tp63 expression.

Chemical Structure

WIC1
WIC1
CAS#943083-58-7

Theoretical Analysis

MedKoo Cat#: 533896

Name: WIC1

CAS#: 943083-58-7

Chemical Formula: C22H23N3O3

Exact Mass: 377.1739

Molecular Weight: 377.44

Elemental Analysis: C, 70.01; H, 6.14; N, 11.13; O, 12.72

Price and Availability

Size Price Availability Quantity
100mg USD 550.00 2 Weeks
200mg USD 950.00 2 Weeks
500mg USD 1,650.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
Synonym
WIC1; WIC-1; WIC 1
IUPAC/Chemical Name
N-(4-(4-Ethylpiperazin-1-yl)phenyl)-2-oxo-2H-chromene-3-carboxamide
InChi Key
YQXKWSNLAVFZJL-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H23N3O3/c1-2-24-11-13-25(14-12-24)18-9-7-17(8-10-18)23-21(26)19-15-16-5-3-4-6-20(16)28-22(19)27/h3-10,15H,2,11-14H2,1H3,(H,23,26)
SMILES Code
O=C(C(C1=O)=CC2=C(O1)C=CC=C2)NC3=CC=C(N4CCN(CC)CC4)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 377.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Aros CJ, Paul MK, Pantoja CJ, Bisht B, Meneses LK, Vijayaraj P, Sandlin JM, France B, Tse JA, Chen MW, Shia DW, Rickabaugh TM, Damoiseaux R, Gomperts BN. High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis. Cell Rep. 2020 Feb 18;30(7):2055-2064.e5. doi: 10.1016/j.celrep.2020.01.059. PMID: 32075752; PMCID: PMC7050206.