MedKoo Cat#: 561299 | Name: N-Desmethyltamoxifen
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

N-Desmethyltamoxifen is the primary metabolite of tamoxifen. It is an estrogen response modifer and protein kinase C inhibitor.

Chemical Structure

N-Desmethyltamoxifen
N-Desmethyltamoxifen
CAS#31750-48-8 (free base)

Theoretical Analysis

MedKoo Cat#: 561299

Name: N-Desmethyltamoxifen

CAS#: 31750-48-8 (free base)

Chemical Formula: C25H27NO

Exact Mass: 357.2093

Molecular Weight: 357.50

Elemental Analysis: C, 83.99; H, 7.61; N, 3.92; O, 4.48

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
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Synonym
N-Desmethyltamoxifen; Desmethyltamoxifen; ICI-55548;
IUPAC/Chemical Name
2-[4-[(Z)-1,2-Diphenylbut-1-enyl]phenoxy]-N-methylethanamine
InChi Key
NYDCDZSEEAUOHN-IZHYLOQSSA-N
InChi Code
InChI=1S/C25H27NO/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2/h4-17,26H,3,18-19H2,1-2H3/b25-24-
SMILES Code
CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ahern TP, Hertz DL, Damkier P, Ejlertsen B, Hamilton-Dutoit SJ, Rae JM, Regan MM, Thompson AM, Lash TL, Cronin-Fenton DP. Cytochrome P-450 2D6 (CYP2D6) Genotype and Breast Cancer Recurrence in Tamoxifen-Treated Patients: Evaluating the Importance of Loss of Heterozygosity. Am J Epidemiol. 2017 Jan 15;185(2):75-85. doi: 10.1093/aje/kww178. Epub 2016 Dec 17. Review. PubMed PMID: 27988492; PubMed Central PMCID: PMC5253974. 2: Morad SA, Cabot MC. Tamoxifen regulation of sphingolipid metabolism--Therapeutic implications. Biochim Biophys Acta. 2015 Sep;1851(9):1134-45. doi: 10.1016/j.bbalip.2015.05.001. Epub 2015 May 9. Review. PubMed PMID: 25964209; PubMed Central PMCID: PMC4516673. 3: Jordan VC. New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer. Steroids. 2007 Nov;72(13):829-42. Epub 2007 Jul 27. Review. PubMed PMID: 17765940; PubMed Central PMCID: PMC2740485. 4: Goetz MP, Loprinzi CL. A hot flash on tamoxifen metabolism. J Natl Cancer Inst. 2003 Dec 3;95(23):1734-5. Review. PubMed PMID: 14652227. 5: White IN. Tamoxifen: is it safe? Comparison of activation and detoxication mechanisms in rodents and in humans. Curr Drug Metab. 2003 Jun;4(3):223-39. Review. PubMed PMID: 12769667. 6: Bachmann-Moisson N, Barberi-Heyob M, Merlin JL, Ledrich ML, Batt AM, Guillemin F. [Cytotoxicity of tamoxifen and its principal metabolites in human breast cancer cell lines]. Bull Cancer. 1996 Oct;83(10):808-15. Review. French. PubMed PMID: 8952630. 7: Pasqualini JR, Sumida C, Giambiagi NA, Nguyen BL. The complexity of anti-estrogen responses. J Steroid Biochem. 1987;27(4-6):883-9. Review. PubMed PMID: 3320567. 8: Jordan VC. Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance. Breast Cancer Res Treat. 1982;2(2):123-38. Review. PubMed PMID: 6184101.