MedKoo Cat#: 561375 | Name: T145

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T145 inhibits growth of Enterococcus faecalis, Staphylococcus aureus and Mycobacterium tuberculosis (Mtb) with sub μg/ml potencies that are potentially therapeutically valuable. T145 minimizes selection of spontaneous resistant mutants, a trait that prolongs longevity of a drug in clinical use.

Chemical Structure

T145
T145
CAS#1021186-98-0

Theoretical Analysis

MedKoo Cat#: 561375

Name: T145

CAS#: 1021186-98-0

Chemical Formula: C18H16N2O5

Exact Mass: 340.1059

Molecular Weight: 340.34

Elemental Analysis: C, 63.53; H, 4.74; N, 8.23; O, 23.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
T145, T-145, T 145
IUPAC/Chemical Name
(S)-N-(3-Dibenzo[1,4]dioxin-2-yl-2-oxo-oxazolidin-5-ylmethyl)-acetamide
InChi Key
CARSFZJMGZOXPN-ZDUSSCGKSA-N
InChi Code
InChI=1S/C18H16N2O5/c1-11(21)19-9-13-10-20(18(22)23-13)12-6-7-16-17(8-12)25-15-5-3-2-4-14(15)24-16/h2-8,13H,9-10H2,1H3,(H,19,21)/t13-/m0/s1
SMILES Code
CC(NC[C@H]1CN(C2=CC=C3OC4=CC=CC=C4OC3=C2)C(O1)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 340.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kaushik A, Heuer AM, Bell DT, Culhane JC, Ebner DC, Parrish N, Ippoliti JT, Lamichhane G. An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3572-6. doi: 10.1016/j.bmcl.2016.06.019. Epub 2016 Jun 9. PubMed PMID: 27329794; PubMed Central PMCID: PMC4955536.