Myrcene | CAS#123-35-3 | olefinic natural organic hydrocarbon

MedKoo Cat#: 591690 | Name: Myrcene

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Myrcene, or β-myrcene, is an olefinic natural organic hydrocarbon. It is more precisely classified as a monoterpene

Chemical Structure

Myrcene

CAS#123-35-3

Theoretical Analysis

MedKoo Cat#: 591690

Name: Myrcene

CAS#: 123-35-3

Chemical Formula: C10H16

Exact Mass: 136.1252

Molecular Weight: 136.24

Elemental Analysis: C, 88.16; H, 11.84

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 220.00

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Related CAS #

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Synonym

Myrcene; NSC 406264; NSC-406264; NSC406264

IUPAC/Chemical Name

1,6-Octadiene, 7-methyl-3-methylene-

InChi Key

UAHWPYUMFXYFJY-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H16/c1-5-10(4)8-6-7-9(2)3/h5,7H,1,4,6,8H2,2-3H3

SMILES Code

C=CC(CC/C=C(C)/C)=C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Myrcene (β-Myrcene), an aromatic volatile compound, suppresses TNFα-induced NF-κB activity.

In vitro activity:

Given the worldwide interest in natural antiphotoaging products, this study investigated the protective effects of myrcene in UVB-irradiated human dermal fibroblasts (NHDFs). This study showed that myrcene decreased the production of ROS, MMP-1, MMP-3, and IL-6, and increased TGF-1 and type I procollagen secretions. Furthermore, myrcene treatment (0.1-10M) dramatically reduced the activation of MAPK-related signaling molecules such as p-ERK, p-p38, and p-JNK and AP-1 including p-c-Jun and p-c-Fos. Reference: Am J Chin Med. 2017;45(5):1113-1124. https://pubmed.ncbi.nlm.nih.gov/28659037/

In vivo activity:

This study investigated the role of β-myrcene on colon inflammation to explore its molecular targets. The result indicated that the administration of β-myrcene in dextran sodium sulfate (DSS)-treated mice restored colon length, decreased disease activity index (DAI), myeloperoxidase (MPO) enzyme activity and suppressed proinflammatory mediators. β-myrcene administration suppressed mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) pathways to limit inflammation. β-myrcene also suppressed mRNA expression of proinflammatory chemokines in tumor necrosis factor-α (TNF-α) challenged HT-29 adenocarcinoma cells. Reference: Molecules. 2022 Dec 9;27(24):8744. https://pubmed.ncbi.nlm.nih.gov/36557879/

	Solvent	mg/mL	mM
Solubility
	DMSO	100.0	734.01
	Ethanol	100.0	734.01

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 136.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Azimullah S, Jayaraj RL, Meeran MFN, Jalal FY, Adem A, Ojha S, Beiram R. Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy. Molecules. 2023 Jan 10;28(2):685. doi: 10.3390/molecules28020685. PMID: 36677744; PMCID: PMC9863310. 2. Hwang E, Ngo HTT, Park B, Seo SA, Yang JE, Yi TH. Myrcene, an Aromatic Volatile Compound, Ameliorates Human Skin Extrinsic Aging via Regulation of MMPs Production. Am J Chin Med. 2017;45(5):1113-1124. doi: 10.1142/S0192415X17500604. Epub 2017 Jun 28. PMID: 28659037. 3. Almarzooqi S, Venkataraman B, Raj V, Alkuwaiti SAA, Das KM, Collin PD, Adrian TE, Subramanya SB. β-Myrcene Mitigates Colon Inflammation by Inhibiting MAP Kinase and NF-κB Signaling Pathways. Molecules. 2022 Dec 9;27(24):8744. doi: 10.3390/molecules27248744. PMID: 36557879; PMCID: PMC9782154. 4. Hu F, Zhou X, Jiang Y, Huang X, Sheng S, Li D. Effect of Myrcene on Th17/Treg Balance and Endocrine Function in Autoimmune Premature Ovarian Insufficiency Mice through the MAPK Signaling Pathway. Protein Pept Lett. 2022;29(11):954-961. doi: 10.2174/0929866529666220822100604. PMID: 35996268.

In vitro protocol:

In vivo protocol:

1. Almarzooqi S, Venkataraman B, Raj V, Alkuwaiti SAA, Das KM, Collin PD, Adrian TE, Subramanya SB. β-Myrcene Mitigates Colon Inflammation by Inhibiting MAP Kinase and NF-κB Signaling Pathways. Molecules. 2022 Dec 9;27(24):8744. doi: 10.3390/molecules27248744. PMID: 36557879; PMCID: PMC9782154. 2. Hu F, Zhou X, Jiang Y, Huang X, Sheng S, Li D. Effect of Myrcene on Th17/Treg Balance and Endocrine Function in Autoimmune Premature Ovarian Insufficiency Mice through the MAPK Signaling Pathway. Protein Pept Lett. 2022;29(11):954-961. doi: 10.2174/0929866529666220822100604. PMID: 35996268.