MedKoo Cat#: 126113 | Name: OC2-K3-E10
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

OC2-K3-E10 is an ionizable lipid for delivery of mRNA in lipid nanoparticles (LNPs). OC2-K3-E10 LNPs delivered Firefly luciferase mRNA when injected intramuscularly in mice and resulted in comparable levels of luminescence as SM-102 LNPs.

Chemical Structure

OC2-K3-E10
OC2-K3-E10
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 126113

Name: OC2-K3-E10

CAS#: N/A

Chemical Formula: C54H111N5O7

Exact Mass: 941.8484

Molecular Weight: 942.51

Elemental Analysis: C, 68.82; H, 11.87; N, 7.43; O, 11.88

Price and Availability

Size Price Availability Quantity
5mg USD 600.00 2 Weeks
10mg USD 1,050.00 2 Weeks
25mg USD 1,650.00 2 Weeks
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Related CAS #
No Data
Synonym
OC2-K3-E10; OC2 K3-E10; OC2-K3 E10; OC2K3-E10; OC2-K3E10; OC2K3E10; OC2 K3 E10
IUPAC/Chemical Name
3,3'-((2-hydroxyethyl)azanediyl)bis(N-(3-(bis(2-hydroxydecyl)amino)propyl)propanamide)
InChi Key
QUXHZASDVBKOSF-UHFFFAOYSA-N
InChi Code
InChI=1S/C54H111N5O7/c1-5-9-13-17-21-25-31-49(61)45-58(46-50(62)32-26-22-18-14-10-6-2)39-29-37-55-53(65)35-41-57(43-44-60)42-36-54(66)56-38-30-40-59(47-51(63)33-27-23-19-15-11-7-3)48-52(64)34-28-24-20-16-12-8-4/h49-52,60-64H,5-48H2,1-4H3,(H,55,65)(H,56,66)
SMILES Code
OCCN(CCC(NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)=O)CCC(NCCCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 942.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
G. Tilstra, J. Couture-Senécal, et al. “Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery” Journal of the American Chemical Society 2023 145 (4), 2294-2304. DOI: 10.1021/jacs.2c10670.