MedKoo Cat#: 593171 | Name: USC-087

Description:

WARNING: This product is for research use only, not for human or veterinary use.

USC-087 is a N-alkyl tyrosinamide phosphonate ester prodrug of HPMPA, the adenine analog of cidofovir, and is highly effective against multiple AdV types in cell culture. USC-087 is a promising candidate for drug development against HAdV infections.

Chemical Structure

USC-087
USC-087
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 593171

Name: USC-087

CAS#: unknown

Chemical Formula: C34H58N7O5P

Exact Mass: 675.4237

Molecular Weight: 675.86

Elemental Analysis: C, 60.42; H, 8.65; N, 14.51; O, 11.84; P, 4.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
USC-087; USC087; USC 087
IUPAC/Chemical Name
(4-((S)-1-amino-2-(hexadecylamino)-2-oxoethyl)benzyl)((((2S)-1-(6-amino-4,5-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphinic acid
InChi Key
HYGAPLJVCRVKAG-NOHNHAJDSA-N
InChi Code
InChI=1S/C34H58N7O5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20-37-34(43)30(35)28-18-16-27(17-19-28)23-47(44,45)26-46-29(22-42)21-41-25-40-31-32(36)38-24-39-33(31)41/h16-19,24-25,29-31,33,42H,2-15,20-23,26,35H2,1H3,(H,37,43)(H,44,45)(H2,36,38,39)/t29-,30-,31?,33?/m0/s1
SMILES Code
NC1=NC=NC2C1N=CN2C[C@@H](CO)OCP(CC3=CC=C([C@H](N)C(NCCCCCCCCCCCCCCCC)=O)C=C3)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 675.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Toth K, Spencer JF, Ying B, Tollefson AE, Hartline CB, Richard ET, Fan J, Lyu J, Kashemirov BA, Harteg C, Reyna D, Lipka E, Prichard MN, McKenna CE, Wold WSM. USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses. Antiviral Res. 2018 May;153:1-9. doi: 10.1016/j.antiviral.2018.03.001. Epub 2018 Mar 3. PubMed PMID: 29510156; PubMed Central PMCID: PMC5891362.