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MedKoo Cat#: 571006 | Name: Duazomycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Duazomycin is an antitumor substance and glutamine antagonist, used as a chemotherapeutic agent.

Chemical Structure

Duazomycin
Duazomycin
CAS#2508-89-6

Theoretical Analysis

MedKoo Cat#: 571006

Name: Duazomycin

CAS#: 2508-89-6

Chemical Formula: C8H11N3O4

Exact Mass: 213.0750

Molecular Weight: 213.19

Elemental Analysis: C, 45.07; H, 5.20; N, 19.71; O, 30.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Duazomycin, Diazomycin A, Duazomycin A, Acetyl-don, NSC 51097
IUPAC/Chemical Name
Norleucine, N-acetyl-6-diazo-5-oxo-, L-
InChi Key
WBSWOKCKZUNHQV-ZETCQYMHSA-N
InChi Code
InChI=1S/C8H11N3O4/c1-5(12)11-7(8(14)15)3-2-6(13)4-10-9/h4,7H,2-3H2,1H3,(H,11,12)(H,14,15)/t7-/m0/s1
SMILES Code
O=C(O)[C@H](CCC(C=[N+]=[N-])=O)NC(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 213.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: ROSENBERG S, CALABRESI P. ENHANCED SUPPRESSION OF THE SECONDARY IMMUNE RESPONSE BY COMBINATION OF 6-MERCAPTOPURINE DUAZOMYCIN A'. Nature. 1963 Sep 14;199:1101-2. PubMed PMID: 14066954. 2: Kaplan SR, Hayslett JP, Calabresi P. Treatment of advanced Wegener's granulomatosis with azathioprine and duazomycin A. N Engl J Med. 1968 Feb 1;278(5):239-44. PubMed PMID: 5635457. 3: Vogel CL, Calabresi P. Enhanced suppression of experimental allergic encephalomyelitis by combination chemotherapy with duazomycin-A and 6-mercaptopurine. Proc Soc Exp Biol Med. 1969 May;131(1):251-6. PubMed PMID: 5770114. 4: Foley HT, Shnider BI, Gold GL, Rius J. A pilot study of methotrexate, duazomycin A, and radiation therapy in carcinoma of the lung. J New Drugs. 1966 Mar-Apr;6(2):105-11. PubMed PMID: 5331283. 5: Lefkowitz ER, Creasey WA, Calabresi P, Sartorelli AC. Clinical and pharmacologic effects of combinations of 6-thioguanine and duazomycin A in patients with neoplastic disease. Cancer Res. 1965 Sep;25(8):1207-12. PubMed PMID: 5839715. 6: Colsky J, Shnider BI, Franzino A, Perez J. Observations in patients with metastatic malignancy treated with duazomycin A. Clin Pharmacol Ther. 1966 May-Jun;7(3):352-8. PubMed PMID: 4957007. 7: ANDERSON EP, BROCKMAN RW. BIOCHEMICAL EFFECTS OF DUAZOMYCIN A IN THE MOUSE PLASMA CELL NEOPLASM 70429. Biochem Pharmacol. 1963 Dec;12:1335-54. PubMed PMID: 14096421.