Synonym
B026; B-026; B 026
IUPAC/Chemical Name
(S)-1'-(2-((S)-7-Fluoro-3-(trifluoromethyl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)-2-oxoethyl)-5-(1-methyl-1H-pyrazol-4-yl)-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-2',5'-dione
InChi Key
DYRHOWZLCQQLTA-HOFKKMOUSA-N
InChi Code
InChI=1S/C28H24F4N4O4/c1-34-12-19(11-33-34)16-2-4-21-17(8-16)6-7-27(21)10-24(37)36(26(27)39)14-25(38)35-13-18-9-20(29)3-5-22(18)40-15-23(35)28(30,31)32/h2-5,8-9,11-12,23H,6-7,10,13-15H2,1H3/t23-,27-/m0/s1
SMILES Code
O=C([C@]12CCC3=C1C=CC(C4=CN(C)N=C4)=C3)N(CC(N5[C@H](C(F)(F)F)COC6=CC=C(F)C=C6C5)=O)C(C2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
556.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yang Y, Zhang R, Li Z, Mei L, Wan S, Ding H, Chen Z, Xing J, Feng H, Han J, Jiang H, Zheng M, Luo C, Zhou B. Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors. J Med Chem. 2020 Feb 13;63(3):1337-1360. doi: 10.1021/acs.jmedchem.9b01721. Epub 2020 Jan 28. PMID: 31910017.
2: Matheson L, Wilding S, Wagland R, Nayoan J, Rivas C, Downing A, Wright P, Brett J, Kearney T, Cross W, Glaser A, Gavin A, Watson E. The psychological impact of being on a monitoring pathway for localised prostate cancer: A UK-wide mixed methods study. Psychooncology. 2019 Jul;28(7):1567-1575. doi: 10.1002/pon.5133. Epub 2019 Jun 10. PMID: 31132801.
3: Haas NL, Coute RA, Hsu CH, Cranford JA, Neumar RW. Descriptive analysis of extracorporeal cardiopulmonary resuscitation following out-of-hospital cardiac arrest-An ELSO registry study. Resuscitation. 2017 Oct;119:56-62. doi: 10.1016/j.resuscitation.2017.08.003. Epub 2017 Aug 5. PMID: 28789990; PMCID: PMC6040225.
4: Chen XS, DI JC, Ma XJ, Liu XM. [Analysis on linkage inheritance of sub-red plant mutant from upland cotton]. Yi Chuan. 2009 Aug;31(8):855-8. Chinese. doi: 10.3724/sp.j.1005.2009.00855. PMID: 19689948.
