MedKoo Cat#: 555719 | Name: Histidine hydrazide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-Histidyl hydrazide, also known as Histidine hydrazide, is a scavenger of 4-hydroxy-2-nonenal. Histidyl hydrazide is effective in reducing brain damage and improving functional outcome in a mouse model of focal ischemic stroke. also protected cultured rat primary neurons against death induced by HNE, chemical hypoxia, glucose deprivation, and combined oxygen and glucose deprivation. Histidine hydrazide prevented neuronal apoptosis as indicated by decreased production of cleaved caspase-3 protein.

Chemical Structure

Histidine hydrazide
Histidine hydrazide
CAS#46119-06-6 (free base)

Theoretical Analysis

MedKoo Cat#: 555719

Name: Histidine hydrazide

CAS#: 46119-06-6 (free base)

Chemical Formula: C6H11N5O

Exact Mass: 169.0964

Molecular Weight: 169.19

Elemental Analysis: C, 42.60; H, 6.55; N, 41.39; O, 9.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
46119-06-6 (free base) 909261-75-2 (sulfate) 118661-75-9 (sulfate) 23508-46-5 (sulfate)
Synonym
L-Histidyl hydrazide; AG01; AG-01; AG 01; Histidine hydrazide;
IUPAC/Chemical Name
(2S)-2-Amino-3-(1H-imidazol-5-yl)propanehydrazide
InChi Key
HIQSHBQGIXVMBC-YFKPBYRVSA-N
InChi Code
InChI=1S/C6H11N5O/c7-5(6(12)11-8)1-4-2-9-3-10-4/h2-3,5H,1,7-8H2,(H,9,10)(H,11,12)/t5-/m0/s1
SMILES Code
N[C@@H](CC1=CNC=N1)C(NN)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 169.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Babizhayev MA, Kasus-Jacobi A. State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases. Curr Clin Pharmacol. 2009 Jan;4(1):4-37. PubMed PMID: 19149498. 2: Babizhayev MA, Guiotto A, Kasus-Jacobi A. N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications. J Drug Target. 2009 Jan;17(1):36-63. doi: 10.1080/10611860802438736 . PubMed PMID: 19037813. 3: Abdo MR, Joseph P, Boigegrain RA, Montero JL, Köhler S, Winum JY. Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide. J Enzyme Inhib Med Chem. 2008 Jun;23(3):357-61. doi: 10.1080/14756360701617107 . PubMed PMID: 18569340. 4: Guiotto A, Ruzza P, Babizhayev MA, Calderan A. Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs. Bioorg Med Chem. 2007 Sep 15;15(18):6158-63. Epub 2007 Jun 20. PubMed PMID: 17604632. 5: Roe MR, Xie H, Bandhakavi S, Griffin TJ. Proteomic mapping of 4-hydroxynonenal protein modification sites by solid-phase hydrazide chemistry and mass spectrometry. Anal Chem. 2007 May 15;79(10):3747-56. Epub 2007 Apr 17. PubMed PMID: 17437329. 6: Han B, Stevens JF, Maier CS. Design, synthesis, and application of a hydrazide-functionalized isotope-coded affinity tag for the quantification of oxylipid-protein conjugates. Anal Chem. 2007 May 1;79(9):3342-54. Epub 2007 Mar 27. PubMed PMID: 17385840.