MedKoo Cat#: 407918 | Name: MDK3627
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK3627, also known as Mutant EGFR inhibitor, is a selective and potent Mutated EGFR inhibitor(L858R activating mutant,

Chemical Structure

MDK3627
MDK3627
CAS#1421373-62-7

Theoretical Analysis

MedKoo Cat#: 407918

Name: MDK3627

CAS#: 1421373-62-7

Chemical Formula: C27H30ClN7O2

Exact Mass: 519.2150

Molecular Weight: 520.03

Elemental Analysis: C, 62.36; H, 5.82; Cl, 6.82; N, 18.85; O, 6.15

Price and Availability

Size Price Availability Quantity
200mg USD 1,750.00 2 Weeks
500mg USD 2,150.00 2 Weeks
1g USD 3,250.00 2 weeks
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Synonym
MDK3627; MDK 3627; MDK-3627; Mutant EGFR inhibitor;
IUPAC/Chemical Name
N-[5-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
InChi Key
SUPQPCQJBYPRPC-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H30ClN7O2/c1-6-25(36)31-21-13-22(24(37-5)14-23(21)35(4)12-11-34(2)3)32-27-30-16-19(28)26(33-27)18-15-29-20-10-8-7-9-17(18)20/h6-10,13-16,29H,1,11-12H2,2-5H3,(H,31,36)(H,30,32,33)
SMILES Code
C=CC(NC1=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 520.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
[1]. WO 2013014448 A1 https://www.freepatentsonline.com/WO2013014448A1.html