Morusin | CAT#62596-29-6 | flavonoid

MedKoo Cat#: 462534 | Name: Morusin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Morusin is a prenylated flavonoid isolated from M. australis with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.

Chemical Structure

Morusin

CAS#62596-29-6

Theoretical Analysis

MedKoo Cat#: 462534

Name: Morusin

CAS#: 62596-29-6

Chemical Formula: C25H24O6

Exact Mass: 420.1573

Molecular Weight: 420.46

Elemental Analysis: C, 71.42; H, 5.75; O, 22.83

Price and Availability

Size	Price	Availability
2mg	USD 250.00	2 Weeks
5mg	USD 430.00	2 Weeks
10mg	USD 640.00	2 Weeks

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Synonym

Morusin

IUPAC/Chemical Name

2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-en-1-yl)-4H,8H-pyrano[2,3-f]chromen-4-one

InChi Key

XFFOMNJIDRDDLQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H24O6/c1-13(2)5-7-17-22(29)21-19(28)12-20-16(9-10-25(3,4)31-20)24(21)30-23(17)15-8-6-14(26)11-18(15)27/h5-6,8-12,26-28H,7H2,1-4H3

SMILES Code

O=C1C2=C(O)C=C3C(C=CC(C)(C)O3)=C2OC(C4=CC=C(O)C=C4O)=C1C/C=C(C)\C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Morusin could inhibit NF-κB and STAT3 activity.

In vitro activity:

Morusin significantly inhibited the growth and clonogenicity of human colorectal cancer HT-29 cells. Apoptosis induced by morusin was characterized by accumulation of cells at the sub-G(1) phase, fragmentation of DNA, and condensation of chromatin. Morusin also inhibited the phosphorylation of IKK-alpha, IKK-beta and IkappaB-alpha, increased expression of IkappaB-alpha, and suppressed nuclear translocation of NF-kappaB and its DNA binding activity. Reference: Biochem Biophys Res Commun. 2008 Jul 18;372(1):236-42. https://pubmed.ncbi.nlm.nih.gov/18485277/

In vivo activity:

To evaluate the growth inhibition effect of morusin on human breast in vivo, human breast cancer bearing-mice were injected with 5 and 10 mg/kg of morusin i. p., 3 times weekly for 4 weeks. Morusin retarded the growth of breast cancer significantly (p < 0.01, (Fig. 5b). Mean tumor weight of the control mice was 1.14 ± 0.30 g, and those of the mice administrated with 5 and 10 mg/kg of morusin were 0.61 ± 0.23 and 0.41 ± 0.10 g, respectively (Fig. 5c), tumor inhibitory rates were 46.5 % (p < 0.05), and 64.1 % (p < 0.01), respectively (Fig. 5d). Reference: J Exp Clin Cancer Res. 2015 Nov 4;34:137. https://pubmed.ncbi.nlm.nih.gov/26538209/

	Solvent	mg/mL	mM
Solubility
	DMF	20.0	47.57
	DMF:PBS (pH 7.2) (1:3)	0.3	0.59
	DMSO	64.7	153.80
	Ethanol	49.5	117.73

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 420.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Lim SL, Park SY, Kang S, Park D, Kim SH, Um JY, Jang HJ, Lee JH, Jeong CH, Jang JH, Ahn KS, Lee SG. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. Am J Cancer Res. 2014 Dec 15;5(1):289-99. PMID: 25628938; PMCID: PMC4300697. 2. Lee JC, Won SJ, Chao CL, Wu FL, Liu HS, Ling P, Lin CN, Su CL. Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. Biochem Biophys Res Commun. 2008 Jul 18;372(1):236-42. doi: 10.1016/j.bbrc.2008.05.023. Epub 2008 May 14. PMID: 18485277. 3. Chen M, Han H, Zhou S, Wen Y, Chen L. Morusin induces osteogenic differentiation of bone marrow mesenchymal stem cells by canonical Wnt/β-catenin pathway and prevents bone loss in an ovariectomized rat model. Stem Cell Res Ther. 2021 Mar 12;12(1):173. doi: 10.1186/s13287-021-02239-3. PMID: 33712069; PMCID: PMC7953707. 4. Li H, Wang Q, Dong L, Liu C, Sun Z, Gao L, Wang X. Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis. J Exp Clin Cancer Res. 2015 Nov 4;34:137. doi: 10.1186/s13046-015-0252-4. PMID: 26538209; PMCID: PMC4634597.

In vitro protocol:

In vivo protocol:

1. Chen M, Han H, Zhou S, Wen Y, Chen L. Morusin induces osteogenic differentiation of bone marrow mesenchymal stem cells by canonical Wnt/β-catenin pathway and prevents bone loss in an ovariectomized rat model. Stem Cell Res Ther. 2021 Mar 12;12(1):173. doi: 10.1186/s13287-021-02239-3. PMID: 33712069; PMCID: PMC7953707. 2. Li H, Wang Q, Dong L, Liu C, Sun Z, Gao L, Wang X. Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis. J Exp Clin Cancer Res. 2015 Nov 4;34:137. doi: 10.1186/s13046-015-0252-4. PMID: 26538209; PMCID: PMC4634597.

1: Li H, Wang Q, Dong L, et al. Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis. J Exp Clin Cancer Res. 2015;34:137. Published 2015 Nov 4. doi:10.1186/s13046-015-0252-4 2: Lee JC, Won SJ, Chao CL, et al. Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. Biochem Biophys Res Commun. 2008;372(1):236-242. doi:10.1016/j.bbrc.2008.05.023 3: Lim SL, Park SY, Kang S, et al. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. Am J Cancer Res. 2014;5(1):289-299. Published 2014 Dec 15.