SD-36 is a potent and selective PROTAC degrader of STAT3, exhibiting a dissociation constant (K<sub>d</sub>) of approximately 50 nM and demonstrating high specificity over other STAT family members. In vitro studies have shown that SD-36 effectively depletes both monomeric and dimeric STAT3 proteins in MOLM-16 cells at a concentration of 1 μM within 5 hours. Additionally, SD-36 suppresses STAT3 transcriptional activity with an IC<sub>50</sub> of 10 nM and inhibits the proliferation of various leukemia and lymphoma cell lines, including MOLM-16, DEL, Karpas-299, KI-JK, SU-DHL-I, and SUP-M2, with IC<sub>50</sub> values below 2 μM. In vivo, SD-36 achieves complete and sustained tumor regression in mouse xenograft models, such as MOLM-16 and SU-DHL-1, at well-tolerated doses ranging from 25 to 100 mg/kg administered intravenously.
MedKoo Cat#: 533484
Name: SD-36 sodium
CAS#: SD-36 sodium
Chemical Formula: C59H60F2N9Na2O12P
Exact Mass: 1157.4224
Molecular Weight: 1202.13
Elemental Analysis: C, 58.95; H, 5.03; F, 3.16; N, 10.49; Na, 3.82; O, 15.97; P, 2.58
The following data is based on the product molecular weight 1,202.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
