CN128 is an orally bioavailable iron chelator. It contains a side chain hydroxy group that acts as an alternate sacrificial glucuronidation site to alleviate metabolic inactivation at the 3-hydroxy group. CN128 increases iron mobilization by 24.8% in a 59Fe-ferritin-loaded rat model of iron overload when administered at doses of 150 and 450 µmol/kg.
MedKoo Cat#: 558988
Name: CN128
CAS#: 2457170-98-6 (free base)
Chemical Formula: C15H18NO3+
Exact Mass: 260.1281
Molecular Weight: 260.31
Elemental Analysis: C, 69.21; H, 6.97; N, 5.38; O, 18.44
The following data is based on the product molecular weight 260.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
