MedKoo Cat#: 574249 | Name: DC-Cholesterol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DC-Chol is a cationic cholesterol derivative. DC-Chol, as a component of lipoplexes with DOPE, has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice.

Chemical Structure

DC-Cholesterol
DC-Cholesterol
CAS#137056-72-5 (free base)

Theoretical Analysis

MedKoo Cat#: 574249

Name: DC-Cholesterol

CAS#: 137056-72-5 (free base)

Chemical Formula: C32H56N2O2

Exact Mass: 500.4340

Molecular Weight: 500.81

Elemental Analysis: C, 76.75; H, 11.27; N, 5.59; O, 6.39

Price and Availability

Size Price Availability Quantity
500mg USD 950.00 2 Weeks
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Synonym
DC-Cholesterol; DC-Chol;
IUPAC/Chemical Name
(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (2-(dimethylamino)ethyl)carbamate
InChi Key
ISXSJGHXHUZXNF-LXZPIJOJSA-N
InChi Code
InChI=1S/C32H56N2O2.ClH/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5;/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35);1H/t23-,25+,26+,27-,28+,29+,31+,32-;/m1./s1
SMILES Code
CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(NCCN(C)C)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.Cl
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 500.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Michel, T., Luft, D., Abraham, M.K., et al. Cationic nanoliposomes meet mRNA: Efficient delivery of modified mRNA using hemocompatible and stable vectors for therapeutic applications. Mol. Ther. Nucleic Acids 8, 459-468 (2017). 2. Gao, J., Sun, J., Li, H., et al. Lyophilized HER2-specific PEGylated immunoliposomes for active siRNA gene silencing. Biomaterials 31(9), 2655-2664 (2010). 3. Zhang, R., Wang, S.B., Chen, A.Z., et al. Codelivery of paclitaxel and small interfering RNA by octadecyl quaternized carboxymethyl chitosan-modified cationic liposome for combined cancer therapy. J. Biomater. Appl. 30(3), 351-360 (2015). 4. Men, Y., Wang, X.X., Li, R.J., et al. The efficacy of mitochondrial targeting antiresistant epirubicin liposomes in treating resistant leukemia in animals. Int. J. Nanomedicine 6, 3125-3137 (2011). 5. Xing, X., Liu, V., Xia, W., et al. Safety studies of the intraperitoneal injection of E1A-liposome complex in mice. Gene Ther. 4(3), 238-243 (1997).