Martinomycin | CAS# 160791-16-2 | Antibiotic

MedKoo Cat#: 574217 | Name: Martinomycin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Martinomycin is a polyether antibiotic active against a variety of bacteria including 11 strains of S. aureus, three strains of S. pneumoniae, and E. faecalis.

Chemical Structure

Martinomycin

CAS#160791-16-2

Theoretical Analysis

MedKoo Cat#: 574217

Name: Martinomycin

CAS#: 160791-16-2

Chemical Formula: C49H84O17

Exact Mass: 944.5709

Molecular Weight: 945.19

Elemental Analysis: C, 62.27; H, 8.96; O, 28.78

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 350.00	2 weeks
5mg	USD 1,085.00	2 weeks

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Synonym

LL-D 37187α, Martinomycin

IUPAC/Chemical Name

(αR,2S,3S,4S,5S,6S)-6-[[(2R,3R,4R,5S,7S,9R,10R)-3,9-dimethoxy-2,4,10-trimethyl-2-[(2S,2'R,5R,5'R)-octahydro-5'-[(2S,3S,4S,5R,6S)-tetrahydro-6-hydroxy-3,5,6-trimethyl-4-[[(2R,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy]-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-1,6-dioxaspiro[4.5]dec-7-yl]methyl]tetrahydro-2-hydroxy-4,5-dimethoxy-α,3,5-trimethyl-2H-pyran-2-acetic acid

InChi Key

VIAPPZHHJMCDEJ-JXBMCXTESA-N

InChi Code

InChI=1S/C49H84O17/c1-24-40(62-39-21-19-32(54-11)30(7)59-39)26(3)47(10,52)65-41(24)35-17-16-33(60-35)34-18-20-37(61-34)46(9)43(57-14)28(5)49(66-46)25(2)36(55-12)22-31(63-49)23-38-45(8,58-15)42(56-13)27(4)48(53,64-38)29(6)44(50)51/h24-43,52-53H,16-23H2,1-15H3,(H,50,51)/t24-,25+,26+,27-,28+,29-,30+,31-,32-,33+,34-,35+,36+,37+,38-,39-,40-,41-,42-,43+,45-,46+,47-,48-,49-/m0/s1

SMILES Code

OC([C@H](C)[C@@]1(O)O[C@](C[C@@H](O2)C[C@@H](OC)[C@@H](C)[C@@]32[C@H](C)[C@@H](OC)[C@]([C@@]4([H])CC[C@]([C@@]5([H])CC[C@@]([C@]6([H])[C@@H](C)[C@H](O[C@@]7([H])CC[C@H](OC)[C@@H](C)O7)[C@@H](C)[C@](O)(C)O6)([H])O5)([H])O4)(C)O3)([H])[C@@](OC)(C)[C@@H](OC)[C@@H]1C)=O

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

Martinomycin is a polyether antibiotic.

In vitro activity:

Actinomycete culture LL-D37187 has been found to produce the new polyether antibiotic martinomycin. Taxonomic studies, including morphological, physiological, and cell wall chemistry analyses, revealed that culture LL-D37187 is a novel streptomycete species, and the proposed name is Streptomyces salvialis. Martinomycin exhibits activity against the Southern Army Worm (Spodoptera eridania) and Gram-positive bacteria. Reference: J Antibiot (Tokyo). 1994 Dec;47(12):1434-41. https://pubmed.ncbi.nlm.nih.gov/7844037/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 945.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Bernan VS, Montenegro DA, Goodman JJ, Alluri MR, Carter GT, Abbanat DR, Pearce CJ, Maiese WM, Greenstein M. Martinomycin, a new polyether antibiotic produced by Streptomyces salvialis. I. Taxonomy, fermentation and biological activity. J Antibiot (Tokyo). 1994 Dec;47(12):1434-41. doi: 10.7164/antibiotics.47.1434. PMID: 7844037.

In vitro protocol:

In vivo protocol:

TBD

1. Carter, G.T., Schlingmann, G., Kenion, G.B., et al. Martinomycin, a new polyether antibiotic produced by Streptomyces salvialis. II. Isolation and structure determination. J. Antibiot. (Tokyo) 47(12), 1549-1553 (1994). 2. Bernan, V.S., Montenegro, D.A., Goodman, J.J., et al. Martinomycin, a new polyether antibiotic produced by Streptomyces salvialis. I. Taxonomy, fermentation and biological activity. J. Antibiot. (Tokyo) 47(12), 1434-1441 (1994).