MedKoo Cat#: 124249 | Name: Gcase activator 2
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator.

Chemical Structure

Gcase activator 2
Gcase activator 2
CAS#2759897-35-1

Theoretical Analysis

MedKoo Cat#: 124249

Name: Gcase activator 2

CAS#: 2759897-35-1

Chemical Formula: C21H24N4O2

Exact Mass: 364.1899

Molecular Weight: 364.45

Elemental Analysis: C, 69.21; H, 6.64; N, 15.37; O, 8.78

Price and Availability

Size Price Availability Quantity
100mg USD 1,650.00 2 Weeks
200mg USD 2,250.00 2 Weeks
500mg USD 3,650.00 2 Weeks
1g USD 4,950.00 2 Weeks
2g USD 7,850.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
compound 14; Gcase activator 2; Gcase-activator-2; Gcase-activator 2
IUPAC/Chemical Name
1-(4-(2-(4-methoxyphenyl)-5-methyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)piperidin-1-yl)ethan-1-one
InChi Key
HEAGFUMRBLFGAD-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H24N4O2/c1-14(26)25-10-8-16(9-11-25)20-12-18-21(24(20)2)22-13-19(23-18)15-4-6-17(27-3)7-5-15/h4-7,12-13,16H,8-11H2,1-3H3
SMILES Code
CC(N1CCC(C2=CC3=NC(C4=CC=C(OC)C=C4)=CN=C3N2C)CC1)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 364.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Benz J, Rufer AC, Huber S, Ehler A, Hug M, Topp A, Guba W, Hofmann EC, Jagasia R, Rodríguez Sarmiento RM. Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew Chem Int Ed Engl. 2021 Mar 1;60(10):5436-5442. doi: 10.1002/anie.202013890. Epub 2021 Jan 19. PMID: 33238058.