MedKoo Cat#: 592287 | Name: GCNU

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GCNU has chemotherapeutic effects on the LSA lymphoma ascites tumor.

Chemical Structure

GCNU
GCNU
CAS# 33073-62-0

Theoretical Analysis

MedKoo Cat#: 592287

Name: GCNU

CAS#: 33073-62-0

Chemical Formula: C17H24ClN3O11

Exact Mass: 481.1099

Molecular Weight: 481.84

Elemental Analysis: C, 42.38; H, 5.02; Cl, 7.36; N, 8.72; O, 36.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
GCNU; NSC 114460; NSC-114460; NSC114460
IUPAC/Chemical Name
1-(2-Chloroethyl)-1-nitroso-3-(1,3,4,6-tetra-O-acetyl-2-deoxy-D-glucopyranos-2-yl)urea
InChi Key
GKFKUZBTGYKBFS-XIHUBIEQSA-N
InChi Code
InChI=1S/C17H24ClN3O11/c1-8(22)28-7-12-14(29-9(2)23)15(30-10(3)24)13(16(32-12)31-11(4)25)19-17(26)21(20-27)6-5-18/h12-16H,5-7H2,1-4H3,(H,19,26)/t12-,13-,14-,15-,16?/m1/s1
SMILES Code
O=C(N[C@H]([C@H]([C@@H]([C@@H](COC(C)=O)O1)OC(C)=O)OC(C)=O)C1OC(C)=O)N(CCCl)N=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 481.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li Z. Computational design and nonlinear dynamics of a recurrent network model of the primary visual cortex. Neural Comput. 2001 Aug;13(8):1749-80. PubMed PMID: 11506669. 2: Feola JM, Maruyama Y. Chemotherapeutic effects of 13 nitrosoureas on the LSA lymphoma ascites tumor of the C57BL mouse. Oncology. 1986;43(6):378-84. PubMed PMID: 3808571. 3: Schiffer D, Giordana MT, Pezzotta S, Paoletti P. Chemotherapeutic effects of some alkylating derivatives of nitrosourea on the development of tumors transplacentally induced in rats by ENU. Acta Neuropathol. 1976 Jan 31;34(1):21-31. PubMed PMID: 175631.