JC1-40 | CAS#N/A

MedKoo Cat#: 533306 | Name: JC1-40

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JC1-40 is a novel RORα activator, diminishing diethylnitrosamine-induced acute liver injury and repressing transcriptional expression of APPs such as CXCL1 and LCN2 in mice.

Chemical Structure

JC1-40

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 533306

Name: JC1-40

CAS#: N/A

Chemical Formula: C16H18N2OS

Exact Mass: 286.1140

Molecular Weight: 286.39

Elemental Analysis: C, 67.10; H, 6.34; N, 9.78; O, 5.59; S, 11.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JC1-40; JC1 40; JC140

IUPAC/Chemical Name

1-(4-Benzyloxy-benzyl)-3-methyl-thiourea

InChi Key

WTJHYYAEJUIEOB-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H18N2OS/c1-17-16(20)18-11-13-7-9-15(10-8-13)19-12-14-5-3-2-4-6-14/h2-10H,11-12H2,1H3,(H2,17,18,20)

SMILES Code

S=C(NC)NCC1=CC=C(OCC2=CC=CC=C2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 286.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kim JY, Han YH, Nam MW, Kim HJ, Lee MO. RORα suppresses interleukin-6-mediated hepatic acute phase response. Sci Rep. 2019 Aug 13;9(1):11798. doi: 10.1038/s41598-019-48171-8. PubMed PMID: 31409825; PubMed Central PMCID: PMC6692401. 2: Han YH, Kim HJ, Na H, Nam MW, Kim JY, Kim JS, Koo SH, Lee MO. RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis. Cell Rep. 2017 Jul 5;20(1):124-135. doi: 10.1016/j.celrep.2017.06.017. PubMed PMID: 28683306. 3: Han YH, Kim DK, Na TY, Ka NL, Choi HS, Lee MO. RORα switches transcriptional mode of ERRγ that results in transcriptional repression of CYP2E1 under ethanol-exposure. Nucleic Acids Res. 2016 Feb 18;44(3):1095-104. doi: 10.1093/nar/gkv1034. Epub 2015 Oct 12. PubMed PMID: 26464440; PubMed Central PMCID: PMC4756810. 4: Han YH, Kim HJ, Kim EJ, Kim KS, Hong S, Park HG, Lee MO. RORα decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice. Antioxid Redox Signal. 2014 Nov 20;21(15):2083-94. doi: 10.1089/ars.2013.5655. Epub 2014 Apr 10. PubMed PMID: 24597775; PubMed Central PMCID: PMC4215383.