K-TMZ | DNA alkylating agent

MedKoo Cat#: 574195 | Name: K-TMZ

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking or expressing O6-methylguanine DNA methyltransferase (MGMT).

Chemical Structure

K-TMZ

CAS#2269482-26-8

Theoretical Analysis

MedKoo Cat#: 574195

Name: K-TMZ

CAS#: 2269482-26-8

Chemical Formula: C7H7N5O2

Exact Mass: 193.0600

Molecular Weight: 193.17

Elemental Analysis: C, 43.53; H, 3.65; N, 36.26; O, 16.57

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	2 Weeks
25mg	USD 950.00	2 Weeks

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Related CAS #

No Data

Synonym

K-TMZ

IUPAC/Chemical Name

8-acetyl-3-methylimidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one

InChi Key

QXYCTGXCOQXVRU-UHFFFAOYSA-N

InChi Code

InChI=1S/C7H7N5O2/c1-4(13)5-6-9-10-11(2)7(14)12(6)3-8-5/h3H,1-2H3

SMILES Code

CN(N=N1)C(N2C1=C(C(C)=O)N=C2)=O

Appearance

A solution in methyl acetate

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

A DNA alkylating agent.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	10.0	51.77
	DMSO	10.0	51.77
	Ethanol	10.0	51.77
	Ethanol:PBS (pH 7.2) (1:2)	0.3	1.55

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 193.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1. Svec, R.L., Furiassi, L., Skibinski, C.G., et al. Tunable stability of imidazotetrazines leads to a potent compound for glioblastoma. ACS Chem. Biol. 13(11), 3206-3216 (2018).