MedKoo Cat#: 124857 | Name: Z16078526
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Z16078526 is a small molecule that enhances UCP1 expression and thermogenesis by modulating the AKAP1/PKA pathway. It promotes mitochondrial activity and energy dissipation, targeting β-adrenergic signaling to activate brown and beige adipocytes. The compound demonstrates potential for metabolic regulation and energy balance improvement.

Chemical Structure

Z16078526
Z16078526
CAS#852222-94-7

Theoretical Analysis

MedKoo Cat#: 124857

Name: Z16078526

CAS#: 852222-94-7

Chemical Formula: C18H17N3O4S

Exact Mass: 371.0940

Molecular Weight: 371.41

Elemental Analysis: C, 58.21; H, 4.61; N, 11.31; O, 17.23; S, 8.63

Price and Availability

Size Price Availability Quantity
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,950.00 2 Weeks
2g USD 6,850.00 2 Weeks
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Related CAS #
No Data
Synonym
Z16078526; Z-16078526; Z 16078526
IUPAC/Chemical Name
N-(2,4-dimethoxyphenyl)-2-((4-oxo-1,4-dihydroquinazolin-2-yl)thio)acetamide
InChi Key
MHSOAGHWQLCVOI-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H17N3O4S/c1-24-11-7-8-14(15(9-11)25-2)19-16(22)10-26-18-20-13-6-4-3-5-12(13)17(23)21-18/h3-9H,10H2,1-2H3,(H,19,22)(H,20,21,23)
SMILES Code
O=C1N=C(NC2=C1C=CC=C2)SCC(NC3=CC=C(C=C3OC)OC)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 371.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Vergnes L, Lin JY, Davies GR, Church CD, Reue K. Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation. J Biol Chem. 2020 Oct 30;295(44):15054-15069. doi: 10.1074/jbc.RA120.013322. Epub 2020 Aug 27. PMID: 32855239; PMCID: PMC7606676.