Neoeriocitrin | CAS# 13241-32-2 | Antioxidant

MedKoo Cat#: 574148 | Name: Neoeriocitrin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neoeriocitrin is a flavonoid that has antioxidative and osteogenic activities. It inhibits the production of DPPH radicals and the formation of superoxide radicals. Neoeriocitrin increases proliferation of MC3T3-E1 osteoblast percursor cells and reverses the antiproliferative effect of the MEK1 inhibitor PD 98059. It also increases the expression of the osteogenic differentiation markers Runx2, Type 1 collagen, and osteocalcin.

Chemical Structure

Neoeriocitrin

CAS#13241-32-2

Theoretical Analysis

MedKoo Cat#: 574148

Name: Neoeriocitrin

CAS#: 13241-32-2

Chemical Formula: C27H32O15

Exact Mass: 596.1741

Molecular Weight: 596.54

Elemental Analysis: C, 54.36; H, 5.41; O, 40.23

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 255.00
5mg	USD 555.00
10mg	USD 940.00
25mg	USD 1,800.00

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Synonym

Eriodictyol 7-O-neohesperidoside, Neoeriocitrin

IUPAC/Chemical Name

(S)-7-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2-(3,4-dihydroxyphenyl)-5-hydroxychroman-4-one

InChi Key

OBKKEZLIABHSGY-DOYQYKRZSA-N

InChi Code

InChI=1S/C27H32O15/c1-9-20(33)22(35)24(37)26(38-9)42-25-23(36)21(34)18(8-28)41-27(25)39-11-5-14(31)19-15(32)7-16(40-17(19)6-11)10-2-3-12(29)13(30)4-10/h2-6,9,16,18,20-31,33-37H,7-8H2,1H3/t9-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1

SMILES Code

O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(O)=C(C(C[C@@H](C3=CC=C(O)C(O)=C3)O4)=O)C4=C2)[C@@H]1O[C@@]5([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.

In vitro activity:

Both neoeriocitrin and naringin exhibited the best effect on proliferation and osteogenic differentiation at concentration of 2μg/ml. Neoeriocitrin more significantly improved proliferation and alkaline phosphatase (ALP) activity as well as up-regulated Runx2, COLI and OCN expression by 56%, 37% and 14% respectively than naringin. Furthermore, neoeriocitrin could rescue the inhibition effect of cell differentiation induced by PD98059 to some degree. Reference: Phytomedicine. 2011 Aug 15;18(11):985-9. https://pubmed.ncbi.nlm.nih.gov/21741227/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	15.0	25.15
	DMSO	65.0	108.96
	DMSO:PBS (pH 7.2) (1:4)	0.2	0.34
	Ethanol	1.0	1.68

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 596.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Li L, Zeng Z, Cai G. Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1. Phytomedicine. 2011 Aug 15;18(11):985-9. doi: 10.1016/j.phymed.2011.03.002. Epub 2011 Jul 7. PMID: 21741227.

In vitro protocol:

In vivo protocol:

TBD

1. Yu, J., Wang, L., Walzem, R.L., et al. Antioxidant activity of citrus limonoids, flavonoids, and coumarins. J. Agric. Food Chem. 53(6), 2009-2014 (2005). 2. Li, L., Zeng, Z., and Cai, G. Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1. Phytomedicine 18(11), 985-989 (2011).