Donitriptan Mesylate| CAS#: 200615-15-2 (mesylate) | 5-HT1B/1D agonist

MedKoo Cat#: 530133 | Name: Donitriptan Mesylate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Donitriptan Mesylate(also spelled Donitriptan mesilate ) is a 5-HT1B/1D agonist potentially for the treatment of migraines.

Chemical Structure

Donitriptan Mesylate

CAS#200615-15-2 (mesylate)

Theoretical Analysis

MedKoo Cat#: 530133

Name: Donitriptan Mesylate

CAS#: 200615-15-2 (mesylate)

Chemical Formula: C24H29N5O5S

Exact Mass:

Molecular Weight: 499.59

Elemental Analysis: C, 57.70; H, 5.85; N, 14.02; O, 16.01; S, 6.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

170912-52-4 (free base) 200615-15-2 (mesylate) 170911-68-9 (HCl)

Synonym

F-12640; F12640; F 12640; Donitriptan mesilate

IUPAC/Chemical Name

4-(4-(2-((3-(2-aminoethyl)-1H-indol-5-yl)oxy)acetyl)piperazin-1-yl)benzonitrile methanesulfonate

InChi Key

YXGLETUJBIBOFT-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H25N5O2.CH4O3S/c24-8-7-18-15-26-22-6-5-20(13-21(18)22)30-16-23(29)28-11-9-27(10-12-28)19-3-1-17(14-25)2-4-19;1-5(2,3)4/h1-6,13,15,26H,7-12,16,24H2;1H3,(H,2,3,4)

SMILES Code

CS(=O)(=O)O.C1CN(CCN1C2=CC=C(C=C2)C#N)C(=O)COC3=CC4=C(C=C3)NC=C4CCN

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 170912-52-4 (Donitriptan, free base) 200615-15-2 (Donitriptan Mesylate

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 499.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Létienne R, Blanchet JC, Sole E, John GW, Le Grand B. Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action? J Pharmacol Exp Ther. 2005 Nov;315(2):849-57. PubMed PMID: 16027226. 2: Muñoz-Islas E, Gupta S, Jiménez-Mena LR, Lozano-Cuenca J, Sánchez-López A, Centurión D, Mehrotra S, MaassenVanDenBrink A, Villalón CM. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91. PubMed PMID: 16880765; PubMed Central PMCID: PMC1629409. 3: Letienne R, Verscheure Y, Perez M, Le Grand B, Colpaert FC, John GW. Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief. J Pharmacol Exp Ther. 2003 May;305(2):749-54. PubMed PMID: 12606602. 4: van den Broek RW, MaassenVanDenBrink A, Mulder PG, Bogers AJ, Avezaat CJ, John GW, Saxena PR. Comparison of contractile responses to donitriptan and sumatriptan in the human middle meningeal and coronary arteries. Eur J Pharmacol. 2002 May 17;443(1-3):125-32. PubMed PMID: 12044802. 5: Tom B, De Vries P, Heiligers JP, Willems EW, Kapoor K, John GW, Saxena PR. Effects of donitriptan on carotid haemodynamics and cardiac output distribution in anaesthetized pigs. Cephalalgia. 2002 Feb;22(1):37-47. PubMed PMID: 11993612. 6: Dukat M. Donitriptan (Pierre Fabre). Curr Opin Investig Drugs. 2001 Mar;2(3):415-8. PubMed PMID: 11575714. 7: Limmroth V, Katsarava Z, Liedert B, Guehring H, Schmitz K, Diener HC, Michel MC. An in vivo rat model to study calcitonin gene related peptide release following activation of the trigeminal vascular system. Pain. 2001 May;92(1-2):101-6. PubMed PMID: 11323131. 8: Mucke H. Therapies in development for the treatment of migraine. Expert Opin Investig Drugs. 2002 Dec;11(12):1813-20. Review. PubMed PMID: 12457440. 9: John GW, Pauwels PJ, Perez M, Halazy S, Le Grand B, Verscheure Y, Valentin JP, Palmier C, Wurch T, Chopin P, Marien M, Kleven MS, Koek W, Assie MB, Carilla-Durand E, Tarayre JP, Colpaert FC. F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. J Pharmacol Exp Ther. 1999 Jul;290(1):83-95. PubMed PMID: 10381763. 10: Bhalla P, Sharma HS, Wurch T, Pauwels PJ, Saxena PR. Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht(1F) receptor. Eur J Pharmacol. 2002 Feb 1;436(1-2):23-33. PubMed PMID: 11834243.

View History

Donitriptan Free Base

MedKoo CAT#: 413890

CAS#: 170912-52-4 (free base)