MedKoo Cat#: 413888 | Name: Donetidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Donetidine is an Antagonist (to Histamine H2 Receptors)

Chemical Structure

Donetidine
Donetidine
CAS#99248-32-5

Theoretical Analysis

MedKoo Cat#: 413888

Name: Donetidine

CAS#: 99248-32-5

Chemical Formula: C20H25N5O3S

Exact Mass: 415.1678

Molecular Weight: 415.51

Elemental Analysis: C, 57.81; H, 6.06; N, 16.86; O, 11.55; S, 7.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Donetidine; SKF93574; SKF-93574; SKF 93574
IUPAC/Chemical Name
4(1H)-Pyrimidinone, 5-((1,2-dihydro-2-oxo-4-pyridinyl)methyl)-2-((2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)amino)-
InChi Key
MURUHMTVTKOWBY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H25N5O3S/c1-25(2)12-16-3-4-17(28-16)13-29-8-7-22-20-23-11-15(19(27)24-20)9-14-5-6-21-18(26)10-14/h3-6,10-11H,7-9,12-13H2,1-2H3,(H,21,26)(H2,22,23,24,27)
SMILES Code
O=C1N=C(NCCSCC2=CC=C(CN(C)C)O2)NC=C1CC(C=CN3)=CC3=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 415.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Machálková M, Schejbal J, Glatz Z, Preisler J. A label-free MALDI TOF MS- based method for studying the kinetics and inhibitor screening of the Alzheimer's disease drug target β-secretase. Anal Bioanal Chem. 2018 Nov;410(28):7441-7448. doi: 10.1007/s00216-018-1354-6. Epub 2018 Sep 15. PMID: 30218128. 2: Jones CA, Conybeare G, Mortensen A, Catto LC, Atterwill CK. SK&F 93574, a histamine H2-receptor antagonist, releases histamine in the dog. J Pharm Pharmacol. 1989 Jan;41(1):68-71. doi: 10.1111/j.2042-7158.1989.tb06335.x. PMID: 2469790. 3: Doyle E, Pearce JC, Picot VS, Lee RM. Analysis of drugs from biological fluids using disposable solid phase columns. J Chromatogr. 1987 Dec 18;411:325-33. doi: 10.1016/s0021-9673(00)93983-9. PMID: 2895114.