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MedKoo Cat#: 585287 | Name: Trospium bromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trospium is used to treat the symptoms of an overactive bladder, such as a frequent need to urinate or incontinence (loss of bladder control). It helps to relax the muscles in the bladder and reduce the daily episodes of incontinence. Trospium is a urinary antispasmodic agent.

Chemical Structure

Trospium bromide
Trospium bromide
CAS#1006028-67-6 (bromide)

Theoretical Analysis

MedKoo Cat#: 585287

Name: Trospium bromide

CAS#: 1006028-67-6 (bromide)

Chemical Formula: C25H30BrNO3

Exact Mass: 392.2220

Molecular Weight: 472.42

Elemental Analysis: C, 63.56; H, 6.40; Br, 16.91; N, 2.96; O, 10.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
10405-02-4 (chloride) 47608-32-2 (cation) 1050405-50-9 (iodide) 1006028-67-6 (bromide) 1006028-56-3 (acetate)
Synonym
Trospium bromide; IP631; IP-631; IP 631; Relaspium;
IUPAC/Chemical Name
[(1S,5R)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-hydroxy-2,2-diphenylacetate bromide
InChi Key
ATACFQVBQCNCFS-DHWZJIOFSA-M
InChi Code
InChI=1S/C25H30NO3.BrH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23?;
SMILES Code
O=C(OC1C[C@]([N+]23CCCC3)([H])CC[C@]2([H])C1)C(C4=CC=CC=C4)(O)C5=CC=CC=C5.[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 472.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Turkoglu AR, Parmak Yener N, Coban S, Guzelsoy M, Emul A, Demirbas M, Demirci H. Effect of trospium chloride therapy on intraocular pressure and tear secretion in overactive bladder patients. Cutan Ocul Toxicol. 2017 Dec;36(4):331-335. doi: 10.1080/15569527.2017.1289219. Epub 2017 May 4. PubMed PMID: 28468509. 2: Geller EJ, Dumond JB, Bowling JM, Khandelwal CM, Wu JM, Busby-Whitehead J, Kaufer DI. Effect of Trospium Chloride on Cognitive Function in Women Aged 50 and Older: A Randomized Trial. Female Pelvic Med Reconstr Surg. 2017 Mar/Apr;23(2):118-123. doi: 10.1097/SPV.0000000000000374. PubMed PMID: 28067745. 3: Abdelhamid MH, Zayed AS, Ghoneima WE, Elmarakbi AA, El Sheemy MS, Aref A, Abdelbary A, Nour HH. Randomized, double-blind, placebo-controlled trial to compare solifenacin versus trospium chloride in the relief of double-J stent-related symptoms. World J Urol. 2017 Aug;35(8):1261-1268. doi: 10.1007/s00345-016-1988-y. Epub 2017 Jan 3. PubMed PMID: 28050642. 4: Tadken T, Weiss M, Modess C, Wegner D, Roustom T, Neumeister C, Schwantes U, Schulz HU, Weitschies W, Siegmund W. Trospium chloride is absorbed from two intestinal "absorption windows" with different permeability in healthy subjects. Int J Pharm. 2016 Dec 30;515(1-2):367-373. doi: 10.1016/j.ijpharm.2016.10.030. Epub 2016 Oct 17. PubMed PMID: 27765726. 5: Madersbacher H, Rovner E. Trospium chloride: the European experience. Expert Opin Pharmacother. 2006 Jul;7(10):1373-80. Review. PubMed PMID: 16805722. 6: Rovner ES. Trospium chloride in the management of overactive bladder. Drugs. 2004;64(21):2433-46. Review. PubMed PMID: 15482001. 7: Notz HJ, Hautumm B, Werdier D, Groves R, Odenthal KP. [Trospium chloride once daily for overactive bladder syndrome: results of a multicenter observational study]. Urologe A. 2013 Jan;52(1):65-70. doi: 10.1007/s00120-012-2989-0. German. PubMed PMID: 23052979. 8: Zinner NR. Trospium chloride: an anticholinergic quaternary ammonium compound for the treatment of overactive bladder. Expert Opin Pharmacother. 2005 Jul;6(8):1409-20. Review. PubMed PMID: 16013990. 9: Yan M, Xue P, Wang K, Gao G, Zhang W, Sun F. Does combination therapy with tamsulosin and trospium chloride improve lower urinary tract symptoms after SEEDS brachytherapy for prostate cancer compared with tamsulosin alone? : A prospective, randomized, controlled trial. Strahlenther Onkol. 2017 Sep;193(9):714-721. doi: 10.1007/s00066-017-1162-5. Epub 2017 Jun 13. PubMed PMID: 28612083. 10: Staskin DR. Trospium chloride: Distinct among other anticholinergic agents available for the treatment of overactive bladder. Urol Clin North Am. 2006 Nov;33(4):465-73, viii. Review. PubMed PMID: 17011382. 11: Biastre K, Burnakis T. Trospium chloride treatment of overactive bladder. Ann Pharmacother. 2009 Feb;43(2):283-95. doi: 10.1345/aph.1L160. Epub 2009 Feb 3. Review. PubMed PMID: 19193592. 12: Doroshyenko O, Jetter A, Odenthal KP, Fuhr U. Clinical pharmacokinetics of trospium chloride. Clin Pharmacokinet. 2005;44(7):701-20. Review. PubMed PMID: 15966754. 13: Kranz J, Petzinger E, Geyer J. Brain penetration of the OAB drug trospium chloride is not increased in aged mice. World J Urol. 2013 Feb;31(1):219-24. doi: 10.1007/s00345-011-0803-z. Epub 2011 Nov 27. PubMed PMID: 22120415; PubMed Central PMCID: PMC3557395. 14: Murgas S, Adolf D. Evaluation of real-world persistence of propiverine and trospium chloride in treatment of overactive bladder in Germany. Res Rep Urol. 2019 Jan 17;11:9-13. doi: 10.2147/RRU.S185278. eCollection 2019. PubMed PMID: 30697533; PubMed Central PMCID: PMC6342142. 15: Karaman A, Samdancı E, Sayın S, Karabulut I, Fadıllıoglu E. Effects of tolterodine and trospium chloride on renal damage induced by partial upper urinary tract obstruction. Urology. 2013 Jul;82(1):194-200. doi: 10.1016/j.urology.2013.01.030. Epub 2013 Feb 28. PubMed PMID: 23453648. 16: Guay DR. Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence. Ther Clin Risk Manag. 2005 Jun;1(2):157-67. PubMed PMID: 18360555; PubMed Central PMCID: PMC1661617. 17: Oefelein MG, Tong W, Kerr S, Bhasi K, Patel RK, Yu D. Effect of concomitant administration of trospium chloride extended release on the steady-state pharmacokinetics of metformin in healthy adults. Clin Drug Investig. 2013 Feb;33(2):123-31. doi: 10.1007/s40261-012-0049-6. PubMed PMID: 23325481; PubMed Central PMCID: PMC3561611. 18: Abulseoud A, Moussa A, Abdelfattah G, Ibrahim I, Saba E, Hassouna M. Transcutaneous posterior tibial nerve electrostimulation with low dose trospium chloride: Could it be used as a second line treatment of overactive bladder in females. Neurourol Urodyn. 2018 Feb;37(2):842-848. doi: 10.1002/nau.23361. Epub 2017 Aug 9. PubMed PMID: 28792105. 19: Singh-Franco D, Machado C, Tuteja S, Zapantis A. Trospium chloride for the treatment of overactive bladder with urge incontinence. Clin Ther. 2005 May;27(5):511-30. Review. PubMed PMID: 15978301. 20: Silver N, Sandage B, Sabounjian L, Schwiderski U, Shipley J, Harnett M. Pharmacokinetics of once-daily trospium chloride 60 mg extended release and twice-daily trospium chloride 20 mg in healthy adults. J Clin Pharmacol. 2010 Feb;50(2):143-50. doi: 10.1177/0091270009345498. Epub 2009 Nov 30. PubMed PMID: 19948948.

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TRV-7019

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