MedKoo Cat#: 564956 | Name: Magnesium L-Threonate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Magnesium L-Threonate is an inhibitor of TNF-α, preventing and restoring memory deficits associated with neuropathic pain.

Chemical Structure

Magnesium L-Threonate
Magnesium L-Threonate
CAS#778571-57-6

Theoretical Analysis

MedKoo Cat#: 564956

Name: Magnesium L-Threonate

CAS#: 778571-57-6

Chemical Formula: C8H14MgO10

Exact Mass: 294.0437

Molecular Weight: 294.50

Elemental Analysis: C, 32.63; H, 4.79; Mg, 8.25; O, 54.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Magnesium L-Threonate
IUPAC/Chemical Name
Magnesium (2R,3S)-2,3,4-trihydroxybutanoate
InChi Key
YVJOHOWNFPQSPP-BALCVSAKSA-L
InChi Code
InChI=1S/2C4H8O5.Mg/c2*5-1-2(6)3(7)4(8)9;/h2*2-3,5-7H,1H2,(H,8,9);/q;;+2/p-2/t2*2-,3+;/m00./s1
SMILES Code
O=C([O-])[C@H](O)[C@@H](O)CO.O=C([O-])[C@H](O)[C@@H](O)CO.[Mg+2]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 294.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xu T, Li D, Zhou X, Ouyang HD, Zhou LJ, Zhou H, Zhang HM, Wei XH, Liu G, Liu XG. Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-α/Nuclear Factor-κB Signaling. Anesthesiology. 2017 Jun;126(6):1151-1168. doi: 10.1097/ALN.0000000000001601. PubMed PMID: 28306698. 2: Wang J, Liu Y, Zhou LJ, Wu Y, Li F, Shen KF, Pang RP, Wei XH, Li YY, Liu XG. Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α. Pain Physician. 2013 Sep-Oct;16(5):E563-75. PubMed PMID: 24077207. 3: Mickley GA, Hoxha N, Luchsinger JL, Rogers MM, Wiles NR. Chronic dietary magnesium-L-threonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion. Pharmacol Biochem Behav. 2013 May;106:16-26. doi: 10.1016/j.pbb.2013.02.019. Epub 2013 Mar 6. PubMed PMID: 23474371; PubMed Central PMCID: PMC3668337.