IUPAC/Chemical Name
2H-1-Benzopyran-2-one, 6-(2,3-dihydroxy-3-methylbutyl)-5,7-dimethoxy-
InChi Key
GLWPLQBQHWYKRK-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H20O6/c1-16(2,19)13(17)7-10-11(20-3)8-12-9(15(10)21-4)5-6-14(18)22-12/h5-6,8,13,17,19H,7H2,1-4H3
SMILES Code
O=C1C=CC2=C(OC)C(CC(O)C(C)(O)C)=C(OC)C=C2O1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
308.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ishii H, Tan S, Wang JP, Chen IS, Ishikawa T. [Studies on the chemical constituents of rutaceous plants. LXVII. The chemical constituents of Toddalia asiatica (L.) Lam. (T. aculeata Pers). Examination of coumarins using supercritical fluid and soxhlet extraction. Is toddalolactone a genuine natural coumarin?]. Yakugaku Zasshi. 1991 Jul;111(7):376-85. Japanese. PubMed PMID: 1783986.
2: Yu B, Zhang G, Jin L, Zhang B, Yan D, Yang H, Ye Z, Ma T. Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum. Front Pharmacol. 2017 Jul 21;8:489. doi: 10.3389/fphar.2017.00489. eCollection 2017. PubMed PMID: 28785222; PubMed Central PMCID: PMC5519579.
3: Liu ZG, Wang XY, Mao BP, Xie XL. [Study on chemical constituents of Toddalia asiatica]. Zhong Yao Cai. 2014 Sep;37(9):1600-3. Chinese. PubMed PMID: 25857161.
4: Lakshmi V, Kapoor S, Pandey K, Patnaik GK. Spasmolytic activity of Toddalia asiatica Var. floribunda. Phytother Res. 2002 May;16(3):281-2. PubMed PMID: 12164278.
5: Ishii H, Kobayashi J, Ishikawa M, Haginiwa J, Ishikawa T. [Studies on the chemical constituents of Rutaceae++ plants. LXVI. The chemical constituents of Toddalia asiatica (L.) Lam. (T. aculeata Pers.). (1). Chemical constituents of the root bark]. Yakugaku Zasshi. 1991 Jul;111(7):365-75. Japanese. PubMed PMID: 1783985.
