Bixalomer is a non-absorbed, orally administered phosphate binder primarily used to treat hyperphosphatemia in patients with chronic kidney disease. In vitro studies indicate that Bixalomer effectively binds phosphate in simulated gastrointestinal conditions, demonstrating a high binding capacity at physiological pH levels. It shows selective adsorption of phosphate ions without significant interactions with other essential ions such as calcium or magnesium. Additionally, Bixalomer does not undergo systemic absorption or metabolic degradation, suggesting its action remains localized within the gastrointestinal tract. These properties contribute to its efficacy in reducing phosphate levels while minimizing systemic side effects.
MedKoo Cat#: 575079
Name: Bixalomer
CAS#: 851373-13-2
Chemical Formula: C19H45ClN6O
Exact Mass: 408.3343
Molecular Weight: 409.06
Elemental Analysis: C, 55.79; H, 11.09; Cl, 8.67; N, 20.55; O, 3.91
The following data is based on the product molecular weight 409.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
