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MedKoo Cat#: 465012 | Name: VUF16839

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VUF16839 is a high-affinity non-imidazole histamine H3 receptor agonist.

Chemical Structure

VUF16839
VUF16839
CAS#2387674-52-2 (free base)

Theoretical Analysis

MedKoo Cat#: 465012

Name: VUF16839

CAS#: 2387674-52-2 (free base)

Chemical Formula: C10H17N5

Exact Mass: 207.1484

Molecular Weight: 207.28

Elemental Analysis: C, 57.95; H, 8.27; N, 33.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2387674-52-2 (free base) VUF16839 HCl
Synonym
VUF16839; VUF 16839; VUF-16839;
IUPAC/Chemical Name
4-(3-(propylamino)azetidin-1-yl)pyrimidin-2-amine
InChi Key
RUMWHMMFUXGDRP-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H17N5/c1-2-4-12-8-6-15(7-8)9-3-5-13-10(11)14-9/h3,5,8,12H,2,4,6-7H2,1H3,(H2,11,13,14)
SMILES Code
NC1=NC(N2CC(NCCC)C2)=CC=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 207.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wágner G, Mocking TAM, Arimont M, Provensi G, Rani B, Silva-Marques B, Latacz G, Da Costa Pereira D, Karatzidou C, Vischer HF, Wijtmans M, Kieć-Kononowicz K, de Esch IJP, Leurs R. 4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H(3) Receptor Agonists with in Vivo Central Nervous System Activity. J Med Chem. 2019 Nov 20. doi: 10.1021/acs.jmedchem.9b01462. [Epub ahead of print] PubMed PMID: 31675226.