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MedKoo Cat#: 532955 | Name: VUF 8430

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VUF 8430 is a histamine agonist selective for the H4 subtype.

Chemical Structure

VUF 8430
VUF 8430
CAS#98021-17-1 (free base)

Theoretical Analysis

MedKoo Cat#: 532955

Name: VUF 8430

CAS#: 98021-17-1 (free base)

Chemical Formula: C4H11N5S

Exact Mass: 161.0735

Molecular Weight: 161.23

Elemental Analysis: C, 29.80; H, 6.88; N, 43.44; S, 19.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
98021-17-1 (free base) 100130-32-3 (HBr)
Synonym
VUF 8430, VUF-8430, VUF8430
IUPAC/Chemical Name
2-(diaminomethylideneamino)ethylsulfanylmethanimidamide
InChi Key
GSYGTVNTZHFQQH-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H11N5S/c5-3(6)9-1-2-10-4(7)8/h1-2H2,(H3,7,8)(H4,5,6,9)
SMILES Code
N=C(SCC/N=C(N)\N)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 161.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sanna MD, Lucarini L, Durante M, Ghelardini C, Masini E, Galeotti N. Histamine H(4) receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress. Br J Pharmacol. 2017 Jan;174(1):28-40. doi: 10.1111/bph.13644. Epub 2016 Nov 18. PubMed PMID: 27714773; PubMed Central PMCID: PMC5341487. 2: García M, García-Pedraza JÁ, Villalón CM, Morán A. Pharmacological Evidence that Histamine H3 Receptors Mediate Histamine-Induced Inhibition of the Vagal Bradycardic Out-flow in Pithed Rats. Basic Clin Pharmacol Toxicol. 2016 Feb;118(2):113-21. doi: 10.1111/bcpt.12475. Epub 2015 Sep 14. PubMed PMID: 26301462. 3: Abiuso AM, Berensztein E, Pagotto RM, Pereyra EN, Medina V, Martinel Lamas DJ, Besio Moreno M, Pignataro OP, Mondillo C. H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells. J Endocrinol. 2014 Dec;223(3):241-53. doi: 10.1530/JOE-14-0401. Epub 2014 Sep 24. PubMed PMID: 25253872. 4: Sim YB, Park SH, Kim SS, Kim CH, Kim SJ, Lim SM, Jung JS, Ryu OH, Choi MG, Suh HW. The modulatory role of spinally located histamine receptors in the regulation of the blood glucose level in d-glucose-fed mice. Korean J Physiol Pharmacol. 2014 Feb;18(1):41-6. doi: 10.4196/kjpp.2014.18.1.41. Epub 2014 Feb 13. PubMed PMID: 24634595; PubMed Central PMCID: PMC3951822. 5: Vasicek O, Lojek A, Jancinova V, Nosal R, Ciz M. Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes. Life Sci. 2014 Mar 28;100(1):67-72. doi: 10.1016/j.lfs.2014.01.082. Epub 2014 Feb 12. PubMed PMID: 24530738. 6: Galeotti N, Sanna MD, Ghelardini C. Pleiotropic effect of histamine H4 receptor modulation in the central nervous system. Neuropharmacology. 2013 Aug;71:141-7. doi: 10.1016/j.neuropharm.2013.03.026. Epub 2013 Apr 11. PubMed PMID: 23583928. 7: Adami M, Pozzoli C, Menozzi A, Bertini S, Passeri B, Cantoni AM, Smits R, de Esch I, Leurs R, Coruzzi G. Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration. Pharmacology. 2012;89(5-6):287-94. doi: 10.1159/000337736. PubMed PMID: 22538763. 8: Massari NA, Medina VA, Martinel Lamas DJ, Cricco GP, Croci M, Sambuco L, Bergoc RM, Rivera ES. Role of H4 receptor in histamine-mediated responses in human melanoma. Melanoma Res. 2011 Oct;21(5):395-404. doi: 10.1097/CMR.0b013e328347ee53. PubMed PMID: 21691231. 9: Rossbach K, Stark H, Sander K, Leurs R, Kietzmann M, Bäumer W. The histamine H receptor as a new target for treatment of canine inflammatory skin diseases. Vet Dermatol. 2009 Oct;20(5-6):555-61. doi: 10.1111/j.1365-3164.2009.00854.x. PubMed PMID: 20178494. 10: Lim HD, de Graaf C, Jiang W, Sadek P, McGovern PM, Istyastono EP, Bakker RA, de Esch IJ, Thurmond RL, Leurs R. Molecular determinants of ligand binding to H4R species variants. Mol Pharmacol. 2010 May;77(5):734-43. doi: 10.1124/mol.109.063040. Epub 2010 Jan 26. PubMed PMID: 20103609. 11: Lim HD, Adami M, Guaita E, Werfel T, Smits RA, de Esch IJ, Bakker RA, Gutzmer R, Coruzzi G, Leurs R. Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430. Br J Pharmacol. 2009 May;157(1):34-43. doi: 10.1111/j.1476-5381.2009.00200.x. PubMed PMID: 19413569; PubMed Central PMCID: PMC2697786. 12: Pozzoli C, Adami M, Smits RA, Coruzzi G. Effect of histamine H4 receptor ligands on cholinergic neurotransmission of the rat duodenum. Inflamm Res. 2009 Apr;58 Suppl 1:59-60. doi: 10.1007/s00011-009-2012-4. PubMed PMID: 19271139. 13: Lim HD, Jongejan A, Bakker RA, Haaksma E, de Esch IJ, Leurs R. Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors. J Pharmacol Exp Ther. 2008 Oct;327(1):88-96. doi: 10.1124/jpet.108.140343. Epub 2008 Jul 17. PubMed PMID: 18635748. 14: Jongejan A, Lim HD, Smits RA, de Esch IJ, Haaksma E, Leurs R. Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations. J Chem Inf Model. 2008 Jul;48(7):1455-63. doi: 10.1021/ci700474a. Epub 2008 Jun 14. PubMed PMID: 18553960. 15: Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G. Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury. Neuroimmunomodulation. 2007;14(6):317-25. doi: 10.1159/000125048. Epub 2008 Apr 10. PubMed PMID: 18401194. 16: Lim HD, Smits RA, Bakker RA, van Dam CM, de Esch IJ, Leurs R. Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem. 2006 Nov 16;49(23):6650-1. PubMed PMID: 17154494.

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