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MedKoo Cat#: 574091 | Name: Pulchinenoside A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pulchinenoside A is a triterpenoid saponin that inhibits NMDA-evoked currents in hippocampal neurons and NMDA-induced neuronal cell death. Pulchinenoside A increases the levels of serotonin (5-HT), 5-hydroxyindolacetic acid (5-HIAA), and norepinephrine in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex. Pulchinenoside A reduces infarct volume in a middle cerebral artery occlusion (MCAO) rat model of ischemia. It also induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner.

Chemical Structure

Pulchinenoside A
Pulchinenoside A
CAS#129724-84-1

Theoretical Analysis

MedKoo Cat#: 574091

Name: Pulchinenoside A

CAS#: 129724-84-1

Chemical Formula: C41H66O12

Exact Mass: 750.4554

Molecular Weight: 750.97

Elemental Analysis: C, 65.58; H, 8.86; O, 25.57

Price and Availability

Size Price Availability Quantity
5mg USD 305.00
10mg USD 530.00
25mg USD 1,015.00
50mg USD 2,000.00
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Related CAS #
No Data
Synonym
Anemoside A3, Pulchinenoside A
IUPAC/Chemical Name
(1R,3aS,5aR,5bR,7aR,8R,9S,11aR,11bR,13aR,13bR)-9-(((2S,3R,4S,5S)-4,5-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid
InChi Key
ISNDTNDJSXYNKT-DVIRKNLQSA-N
InChi Code
InChI=1S/C41H66O12/c1-20(2)22-10-15-41(36(48)49)17-16-39(6)23(28(22)41)8-9-26-37(4)13-12-27(38(5,19-42)25(37)11-14-40(26,39)7)52-35-33(30(45)24(43)18-50-35)53-34-32(47)31(46)29(44)21(3)51-34/h21-35,42-47H,1,8-19H2,2-7H3,(H,48,49)/t21-,22-,23+,24-,25+,26+,27-,28+,29-,30-,31+,32+,33+,34-,35-,37-,38-,39+,40+,41-/m0/s1
SMILES Code
CC([C@@H]1CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])[C@](C)(CO)[C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O7)[C@@H](O)[C@@H](O)CO6)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H])=C
Appearance
Solid powder
Purity
>90% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 750.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zhang, D.-M., Lin, S.-M., Lau, C.-W., et al. Anemoside A3-induced relaxation in rat renal arteries: Role of endothelium and Ca2+ channel inhibition. Planta Med. 76(16), 1814-1819 (2010). 2. Ip, F.C.F., Fu, W.-Y., Cheng, E.Y.L., et al. Anemoside A3 enhances cognition through the regulation of synaptic function and neuroprotection. Neuropsychopharmacology 40(8), 1877-1887 (2015).

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