MedKoo Cat#: 555677 | Name: DAVP-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DAVP-1 is a HIV-1 reverse transcriptase inhibitor. DAVP-1 binds at a hinge between the palm and thumb subdomains that may distort the dNTP-binding site (N-site).

Chemical Structure

DAVP-1
DAVP-1
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 555677

Name: DAVP-1

CAS#: Unknown

Chemical Formula:

Exact Mass:

Molecular Weight:

Elemental Analysis:

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DAVP-1; DAVP 1; DAVP1;
IUPAC/Chemical Name
4-dimethylamino-6-vinylpyrimidine
InChi Key
GFZDHKFQHAEMGL-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H11N3/c1-4-7-5-8(11(2)3)10-6-9-7/h4-6H,1H2,2-3H3
SMILES Code
C=CC1=CC(N(C)C)=NC=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: La J, Latham CF, Tinetti RN, Johnson A, Tyssen D, Huber KD, Sluis-Cremer N, Simpson JS, Headey SJ, Chalmers DK, Tachedjian G. Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening. Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6979-84. doi: 10.1073/pnas.1423900112. Epub 2015 May 18. PubMed PMID: 26038551; PubMed Central PMCID: PMC4460473. 2: Bellucci L, Angeli L, Tafi A, Radi M, Botta M. Unconventional plasticity of HIV-1 reverse transcriptase: how inhibitors could open a connection "gate" between allosteric and catalytic sites. J Chem Inf Model. 2013 Dec 23;53(12):3117-22. doi: 10.1021/ci400414s. Epub 2013 Nov 25. PubMed PMID: 24256065. 3: Freisz S, Bec G, Radi M, Wolff P, Crespan E, Angeli L, Dumas P, Maga G, Botta M, Ennifar E. Crystal structure of HIV-1 reverse transcriptase bound to a non-nucleoside inhibitor with a novel mechanism of action. Angew Chem Int Ed Engl. 2010 Mar 1;49(10):1805-8. doi: 10.1002/anie.200905651. PubMed PMID: 20135654. 4: Guillon G, Pena A, Murat B, Derick S, Trueba M, Ventura MA, Szeto HH, Wo N, Stoev S, Cheng LL, Manning M. Position 4 analogues of [deamino-Cys(1)] arginine vasopressin exhibit striking species differences for human and rat V(2)/V(1b) receptor selectivity. J Pept Sci. 2006 Mar;12(3):190-8. PubMed PMID: 16130178. 5: Lammek B, Bankowski K, Misicka A, Manning M, Seto J, Sawyer WH. 2-O-alkyltyrosine derivatives of 1-deamino-arginine-vasopressin: highly specific and potent antidiuretic agonists. J Med Chem. 1989 Jan;32(1):244-7. PubMed PMID: 2909737.