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MedKoo Cat#: 592990 | Name: Asobamast
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Asobamast is an antiallergic and anti-asthmatic agent. Asobamast against IgE-mediated passive pulmonary anaphylaxis in rats and showed a potent inhibition of antigen-induced mediator release from sensitized guinea pig lung fragments.

Chemical Structure

Asobamast
Asobamast
CAS#104777-03-9

Theoretical Analysis

MedKoo Cat#: 592990

Name: Asobamast

CAS#: 104777-03-9

Chemical Formula: C13H15N3O5S

Exact Mass: 325.0732

Molecular Weight: 325.34

Elemental Analysis: C, 47.99; H, 4.65; N, 12.92; O, 24.59; S, 9.85

Price and Availability

Size Price Availability Quantity
1mg USD 90.00 Ready to Ship
5mg USD 150.00 Ready to Ship
10mg USD 250.00 Ready to Ship
25mg USD 550.00 Ready to Ship
50mg USD 950.00 Ready to Ship
100mg USD 1,650.00 Ready to Ship
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Related CAS #
No Data
Synonym
Asobamast
IUPAC/Chemical Name
2-Ethoxyethyl (4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate
InChi Key
IKYTUOHXXXPNOG-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H15N3O5S/c1-3-19-4-5-20-12(18)11(17)15-13-14-9(7-22-13)10-6-8(2)16-21-10/h6-7H,3-5H2,1-2H3,(H,14,15,17)
SMILES Code
O=C(NC1=NC(C2=CC(C)=NO2)=CS1)C(OCCOCC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Biological target:
Asobamast is an antiallergic and anti-asthmatic agent.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 325.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
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PMID: 32461978; PMCID: PMC7243011. 5: Baba A, Tachi M, Ejima Y, Endo Y, Toyama H, Matsubara M, Saito K, Yamauchi M, Miura C, Kazama I. Anti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties. Cell Physiol Biochem. 2016;38(1):15-27. doi: 10.1159/000438605. Epub 2016 Jan 8. PMID: 26741745. 6: Baba A, Tachi M, Ejima Y, Endo Y, Toyama H, Saito K, Abe N, Yamauchi M, Miura C, Kazama I. Less contribution of mast cells to the progression of renal fibrosis in Rat kidneys with chronic renal failure. Nephrology (Carlton). 2017 Feb;22(2):159-167. doi: 10.1111/nep.12733. PMID: 26840502. 7: Uddin Ahmed AF, Ohtani H, Nio M, Funaki N, Sasaki H, Nagura H, Ohi R. Intrahepatic mast cell population correlates with clinical outcome in biliary atresia. J Pediatr Surg. 2000 Dec;35(12):1762-5. doi: 10.1053/jpsu.2000.19245. PMID: 11101732. 8: Efergan A, Azouz NP, Klein O, Noguchi K, Rothenberg ME, Fukuda M, Sagi- Eisenberg R. Rab12 Regulates Retrograde Transport of Mast Cell Secretory Granules by Interacting with the RILP-Dynein Complex. J Immunol. 2016 Feb 1;196(3):1091-101. doi: 10.4049/jimmunol.1500731. Epub 2016 Jan 6. PMID: 26740112. 9: Itoh T, Kojimoto A, Uchida K, Chambers J, Shii H. Long-term postsurgical outcomes of mast cell tumors resected with a margin proportional to the tumor diameter in 23 dogs. J Vet Med Sci. 2021 Feb 25;83(2):230-233. doi: 10.1292/jvms.20-0281. Epub 2020 Dec 21. PMID: 33342962; PMCID: PMC7972896. 10: Fukuda M. Rab27 effectors, pleiotropic regulators in secretory pathways. Traffic. 2013 Sep;14(9):949-63. doi: 10.1111/tra.12083. Epub 2013 Jun 10. PMID: 23678941. 11: Kazama I, Maruyama Y, Takahashi S, Kokumai T. Amphipaths differentially modulate membrane surface deformation in rat peritoneal mast cells during exocytosis. Cell Physiol Biochem. 2013;31(4-5):592-600. doi: 10.1159/000350079. Epub 2013 Apr 26. PMID: 23635874. 12: Ito C. Histamine H3-receptor inverse agonists as novel antipsychotics. Cent Nerv Syst Agents Med Chem. 2009 Jun;9(2):132-6. doi: 10.2174/187152409788452036. PMID: 20021346. 13: Kaneko I, Hishinuma T, Suzuki K, Owada Y, Kitanaka N, Kondo H, Goto J, Furukawa H, Ono M. Prostaglandin F(2alpha) regulates cytokine responses of mast cells through the receptors for prostaglandin E. Biochem Biophys Res Commun. 2008 Mar 14;367(3):590-6. doi: 10.1016/j.bbrc.2008.01.002. Epub 2008 Jan 9. PMID: 18190789. 14: Ohtsu H, Tanaka S, Terui T, Hori Y, Makabe-Kobayashi Y, Pejler G, Tchougounova E, Hellman L, Gertsenstein M, Hirasawa N, Sakurai E, Buzás E, Kovács P, Csaba G, Kittel A, Okada M, Hara M, Mar L, Numayama-Tsuruta K, Ishigaki-Suzuki S, Ohuchi K, Ichikawa A, Falus A, Watanabe T, Nagy A. Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett. 2001 Jul 27;502(1-2):53-6. doi: 10.1016/s0014-5793(01)02663-1. PMID: 11478947. 15: Watanabe T, Ohtsu H. L-histidine decarboxylase as a probe in studies on histamine. Chem Rec. 2002;2(6):369-76. doi: 10.1002/tcr.10036. PMID: 12469348. 16: Endo Y. [Induction of histidine decarboxylase in inflammation and immune responses]. Nihon Yakurigaku Zasshi. 2001 Jul;118(1):5-14. Japanese. doi: 10.1254/fpj.118.5. PMID: 11496827. 17: Zhang MC, Furukawa H, Tokunaka K, Saiga K, Date F, Owada Y, Nose M, Ono M. Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice. Immunogenetics. 2008 Oct;60(10):599-607. doi: 10.1007/s00251-008-0320-4. Epub 2008 Aug 2. PMID: 18677469. 18: Kanaya A, Yang M, Emala C, Mikami M. Chronic allergic lung inflammation negatively influences neurobehavioral outcomes in mice. J Neuroinflammation. 2022 Aug 31;19(1):210. doi: 10.1186/s12974-022-02575-y. PMID: 36045388; PMCID: PMC9429782. 19: Kishi T, Kawana H, Sayama M, Makide K, Inoue A, Otani Y, Ohwada T, Aoki J. Identification of lysophosphatidylthreonine with an aromatic fatty acid surrogate as a potent inducer of mast cell degranulation. Biochem Biophys Rep. 2016 Oct 8;8:346-351. doi: 10.1016/j.bbrep.2016.09.013. PMID: 28955975; PMCID: PMC5613971. 20: Kuramasu A, Saito H, Suzuki S, Watanabe T, Ohtsu H. Mast cell-/basophil- specific transcriptional regulation of human L-histidine decarboxylase gene by CpG methylation in the promoter region. J Biol Chem. 1998 Nov 20;273(47):31607-14. doi: 10.1074/jbc.273.47.31607. PMID: 9813077.