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MedKoo Cat#: 561373 | Name: Acetylpepstatin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Acetylpepstatin is an inhibitor of aspartyl protease and both HIV-1 and HIV-2 proteases.

Chemical Structure

Acetylpepstatin
Acetylpepstatin
CAS#28575-34-0

Theoretical Analysis

MedKoo Cat#: 561373

Name: Acetylpepstatin

CAS#: 28575-34-0

Chemical Formula: C31H57N5O9

Exact Mass: 643.4156

Molecular Weight: 643.82

Elemental Analysis: C, 57.83; H, 8.92; N, 10.88; O, 22.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Acetylpepstatin; Acetyl-pepstatin; Ac-Val-Val-Sta-Ala-Sta-OH;
IUPAC/Chemical Name
(3S,4S)-4-[[(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoic acid
InChi Key
WKYBEGDEGRCZNF-LBTYKNIQSA-N
InChi Code
InChI=1S/C31H57N5O9/c1-15(2)11-21(35-30(44)28(18(7)8)36-31(45)27(17(5)6)33-20(10)37)23(38)13-25(40)32-19(9)29(43)34-22(12-16(3)4)24(39)14-26(41)42/h15-19,21-24,27-28,38-39H,11-14H2,1-10H3,(H,32,40)(H,33,37)(H,34,43)(H,35,44)(H,36,45)(H,41,42)/t19-,21-,22-,23-,24-,27-,28-/m0/s1
SMILES Code
CC(C)C[C@H](NC([C@@H](NC(C[C@H](O)[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)C(C)C)=O)C(C)C)=O)CC(C)C)=O)C)=O)[C@@H](O)CC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 643.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Roberts LR, Adjei PN, Gores GJ. Cathepsins as effector proteases in hepatocyte apoptosis. Cell Biochem Biophys. 1999;30(1):71-88. Review. PubMed PMID: 10099823. 2: Mothes E, Shoeman RL, Traub P. Pepstatin A: polymerization of an oligopeptide. Micron. 1994;25(2):189-217. Review. PubMed PMID: 8055247. 3: Fujisawa Y, Kakinuma A. [HIV protease inhibitors]. Tanpakushitsu Kakusan Koso. 1993 Aug;38(11):2012-30. Review. Japanese. PubMed PMID: 8210441. 4: Haber E. Will renin inhibitors influence decision-making in antihypertensive therapy? J Hypertens Suppl. 1985 Nov;3(2):S71-80. Review. PubMed PMID: 3003303. 5: Geshelin SA, Vovchuk SV, Blizniuk BF, Varbanets VF. [Proteolytic enzymes and their inhibitors in clinical and experimental oncology]. Vopr Onkol. 1984;30(10):9-18. Review. Russian. PubMed PMID: 6208687. 6: Hofbauer KG, Wood JM. Inhibition of renin: recent developments. Contrib Nephrol. 1984;43:144-52. Review. PubMed PMID: 6207982. 7: Ganten D, Paul M, Deboben A, Unger T, Lang RE. The brain renin angiotensin system in central cardiovascular control. Contrib Nephrol. 1984;43:114-28. Review. PubMed PMID: 6207981. 8: Ganten D, Unger T, Lang RE. Pharmacological interferences with the renin-angiotensin system. Arzneimittelforschung. 1984;34(10B):1391-8. Review. PubMed PMID: 6097263.