GSK3527497 is a potent and selective inhibitor of Transient Receptor Potential Vanilloid‑4 (TRPV4) with IC50 = 12 nM) for the treatment of heart failure and respiratory diseases. GSK3527497 is a preclinical candidate suitable for oral and iv administration that is projected to inhibit TRPV4 effectively in patients from a low daily clinical dose.
MedKoo Cat#: 555655
Name: GSK3527497 HCl
CAS#: 2215855-51-7 (HCl)
Chemical Formula: C17H17Cl2FN4O4S
Exact Mass:
Molecular Weight: 463.31
Elemental Analysis: C, 44.07; H, 3.70; Cl, 15.30; F, 4.10; N, 12.09; O, 13.81; S, 6.92
The following data is based on the product molecular weight 463.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
